Zinc finger protein 426

ZNF426
Identifiers
Aliases	ZNF426, K-RBP, zinc finger protein 426
External IDs	MGI: 1920248 HomoloGene: 23435 GeneCards: ZNF426
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 9,523,224 bp[1] End 9,538,645 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A3|9 7.55 cM Start 20,468,549 bp[2] End 20,492,746 bp[2]
Gene ontology Molecular function • DNA binding • protein binding • metal ion binding • nucleic acid binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding Cellular component • intracellular • cell nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79088	235028
Ensembl	ENSG00000130818	ENSMUSG00000059475
UniProt	Q9BUY5	Q8R1D1
RefSeq (mRNA)	NM_001300883 NM_024106 NM_001318055 NM_001318056	NM_001110309 NM_146221 NM_001310742
RefSeq (protein)	NP_001287812 NP_001304984 NP_001304985 NP_077011	NP_001103779 NP_001297671 NP_666333
Location (UCSC)	Chr 19: 9.52 – 9.54 Mb	Chr 9: 20.47 – 20.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein 426 is a protein that in humans is encoded by the ZNF426 gene. ^[5]

Function

Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.