Uracil/thymine dehydrogenase

Uracil/thymine dehydrogenase
Identifiers
EC number 1.17.99.4
CAS number 9029-00-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Uracil/thymine dehydrogenase (EC 1.17.99.4, uracil oxidase, uracil-thymine oxidase, uracil dehydrogenase) is an enzyme with systematic name uracil:acceptor oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

(1) uracil + H2O + acceptor barbiturate + reduced acceptor
(2) thymine + H2O + acceptor 5-methylbarbiturate + reduced acceptor

Uracil/thymine dehydrogenase forms part of the oxidative pyrimidine-degrading pathway in some microorganisms.

References

  1. ↑ Hayaishi, O.; Kornberg, A. (1952). "Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes". J. Biol. Chem. 197 (2): 717–723. PMID 12981104.
  2. ↑ Wang, T.P.; Lampen, J.O. (1952). "Metabolism of pyrimidines by a soil bacterium". J. Biol. Chem. 194 (2): 775–783. PMID 14927671.
  3. ↑ Wang, T.P.; Lampen, J.O. (1952). "Uracil oxidase and the isolation of barbituric acid from uracil oxidation". J. Biol. Chem. 194 (2): 785–791. PMID 14927672.
  4. ↑ Lara, F.J.S. (1952). "On the decomposition of pyrimidines by bacteria. II. Studies with cell-free enzyme preparations". J. Bacteriol. 64 (2): 279–285. PMC 169350. PMID 14955523.
  5. ↑ Soong, C.L.; Ogawa, J.; Shimizu, S. (2001). "Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase". Biochem. Biophys. Res. Commun. 286: 222–226. doi:10.1006/bbrc.2001.5356. PMID 11485332.
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