Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase

Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
Identifiers
EC number 2.7.8.30
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (EC 2.7.8.30, undecaprenyl-phosphate Ara4FN transferase, Ara4FN transferase, polymyxin resistance protein PmrF, UDP-4-amino-4-deoxy-alpha-L-arabinose:ditrans,polycis-undecaprenyl phosphate 4-amino-4-deoxy-alpha-L-arabinosyltransferase) is an enzyme with systematic name UDP-4-amino-4-deoxy-alpha-L-arabinose:ditrans,octacis-undecaprenyl phosphate 4-amino-4-deoxy-alpha-L-arabinosyltransferase.[1][2] This enzyme catalyses the following chemical reaction

UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans,octacis-undecaprenyl phosphate UDP + 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate

The enzyme shows no activity with UDP-4-amino-4-deoxy-beta-L-arabinose.

References

  1. ↑ Breazeale, S.D.; Ribeiro, A.A.; Raetz, C.R. (2002). "Oxidative decarboxylation of UDP-glucuronic acid in extracts of polymyxin-resistant Escherichia coli. Origin of lipid a species modified with 4-amino-4-deoxy-L-arabinose". J. Biol. Chem. 277 (4): 2886–2896. doi:10.1074/jbc.M109377200. PMID 11706007.
  2. ↑ Breazeale, S.D.; Ribeiro, A.A.; McClerren, A.L.; Raetz, C.R.H. (2005). "A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-amino-4-deoxy-L-arabinose. Identification and function of UDP-4-deoxy-4-formamido-L-arabinose". J. Biol. Chem. 280: 14154–14167. doi:10.1074/jbc.M414265200. PMID 15695810.
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