UDP-4-amino-4-deoxy-L-arabinose aminotransferase

UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Identifiers
EC number 2.6.1.87
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

UDP-4-amino-4-deoxy-L-arabinose aminotransferase (EC 2.6.1.87, UDP-(beta-L-threo-pentapyranosyl-4-ulose diphosphate) aminotransferase, UDP-4-amino-4-deoxy-L-arabinose---oxoglutarate aminotransferase, UDP-Ara4O aminotransferase, UDP-L-Ara4N transaminase) is an enzyme with systematic name UDP-4-amino-4-deoxy-beta-L-arabinose:2-oxoglutarate aminotransferase.[1][2] This enzyme catalyses the following chemical reaction

UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate

This protein is a pyridoxal 5'-phosphate enzyme.

References

  1. ↑ Breazeale, S.D.; Ribeiro, A.A.; Raetz, C.R. (2003). "Origin of lipid A species modified with 4-amino-4-deoxy-L-arabinose in polymyxin-resistant mutants of Escherichia coli. An aminotransferase (ArnB) that generates UDP-4-deoxyl-L-arabinose". J. Biol. Chem. 278 (27): 24731–24739. doi:10.1074/jbc.m304043200. PMID 12704196.
  2. ↑ Noland, B.W.; Newman, J.M.; Hendle, J.; Badger, J.; Christopher, J.A.; Tresser, J.; Buchanan, M.D.; Wright, T.A.; Rutter, M.E.; Sanderson, W.E.; Muller-Dieckmann, H.J.; Gajiwala, K.S.; Buchanan, S.G. (2002). "Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme". Structure. 10 (11): 1569–1580. doi:10.1016/s0969-2126(02)00879-1. PMID 12429098.
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