UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase

UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase
Identifiers
EC number 2.6.1.91
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase (EC 2.6.1.91, pglE (gene)) is an enzyme with systematic name UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine:2-oxoglutarate aminotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine + 2-oxoglutarate UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + L-glutamate

This enzyme is a pyridoxal-phosphate protein.

References

  1. ↑ Olivier, N.B.; Chen, M.M.; Behr, J.R.; Imperiali, B. (2006). "In vitro biosynthesis of UDP-N,N′-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system". Biochemistry. 45: 13659–13669. doi:10.1021/bi061456h. PMC 2542654. PMID 17087520.
  2. ↑ Schoenhofen, I.C.; McNally, D.J.; Vinogradov, E.; Whitfield, D.; Young, N.M.; Dick, S.; Wakarchuk, W.W.; Brisson, J.R.; Logan, S.M. (2006). "Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways". J. Biol. Chem. 281: 723–732. doi:10.1074/jbc.m511021200. PMID 16286454.
  3. ↑ Rangarajan, E.S.; Ruane, K.M.; Sulea, T.; Watson, D.C.; Proteau, A.; Leclerc, S.; Cygler, M.; Matte, A.; Young, N.M. (2008). "Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter jejuni". Biochemistry. 47: 1827–1836. doi:10.1021/bi702032r. PMID 18198901.
  4. ↑ Hartley, M.D.; Morrison, M.J.; Aas, F.E.; Borud, B.; Koomey, M.; Imperiali, B. (2011). "Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N′-diacetylbacillosamine". Biochemistry. 50: 4936–4948. doi:10.1021/bi2003372. PMC 3108506. PMID 21542610.
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