UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase

UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase
Identifiers
EC number 2.3.1.201
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase (EC 2.3.1.201, WbpD, WlbB) is an enzyme with systematic name acetyl-CoA:UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate N-acetyltransferase.[1][2] This enzyme catalyses the following chemical reaction

acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate CoA + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate

This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid).

References

  1. ↑ Westman, E.L.; McNally, D.J.; Charchoglyan, A.; Brewer, D.; Field, R.A.; Lam, J.S. (2009). "Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa". J. Biol. Chem. 284: 11854–11862. doi:10.1074/jbc.M808583200. PMC 2673254. PMID 19282284.
  2. ↑ Larkin, A.; Imperiali, B. (2009). "Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1". Biochemistry. 48: 5446–5455. doi:10.1021/bi900186u. PMC 2694220. PMID 19348502.
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