UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase

UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase
Identifiers
EC number 2.6.1.98
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase (EC 2.6.1.98, WbpE, WlbC) is an enzyme with systematic name UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate:2-oxoglutarate aminotransferase.[1][2][3] This enzyme catalyses the following chemical reaction

UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate + 2-oxoglutarate UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + L-glutamate

This enzyme is a pyridoxal 5'-phosphate protein.

References

  1. ↑ Westman, E.L.; McNally, D.J.; Charchoglyan, A.; Brewer, D.; Field, R.A.; Lam, J.S. (2009). "Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa". J. Biol. Chem. 284 (18): 11854–11862. doi:10.1074/jbc.M808583200. PMC 2673254. PMID 19282284.
  2. ↑ Larkin, A.; Imperiali, B. (2009). "Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1". Biochemistry. 48 (23): 5446–5455. doi:10.1021/bi900186u. PMC 2694220. PMID 19348502.
  3. ↑ Larkin, A.; Olivier, N.B.; Imperiali, B. (2010). "Structural analysis of WbpE from Pseudomonas aeruginosa PAO1: a nucleotide sugar aminotransferase involved in O-antigen assembly". Biochemistry. 49 (33): 7227–7237. doi:10.1021/bi100805b. PMC 2923267. PMID 20604544.
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