Hepatitis A and B vaccine

Hepatitis A and B vaccine
Combination of
Hepatitis A Vaccine
Hepatitis B Vaccine
Clinical data
Trade names Twinrix, Twinrix Adult, AmBirix, Twinrix Jr, Twinrix Paediatric
AHFS/Drugs.com FDA Professional Drug Information
Pregnancy
category
  • US: C (Risk not ruled out)
    Routes of
    administration    		 Intramuscular injection
    ATC code
    Identifiers
    CAS Number
    ChemSpider
    • none

    Twinrix is a vaccine against hepatitis A and hepatitis B, manufactured by GlaxoSmithKline. The full generic name is hepatitis A (inactivated) and hepatitis B (rDNA) (HAB) vaccine (adsorbed). Twinrix is administered over three doses.

    The name was created because it is a mixture of two earlier vaccines — Havrix, an inactivated-virus Hepatitis A vaccine, and Engerix-B, a recombinant Hepatitis B vaccine. Twinrix, Havrix and Engerix-B are registered trademarks of GlaxoSmithKline. Twinrix first entered the market in early 1997.

    In some countries outside the USA, notably Canada and Europe, Twinrix is known as Twinrix Adult or AmBirix and a pediatric formulation, called Twinrix Jr or Twinrix Paediatric, is available.

    Administration schedule

    Twinrix can be administered on the same schedule as monovalent Hepatitis B vaccine: at 0- 1- and 6- months. In some circumstances, an accelerated dosing schedule of 0- 7- and 21-to 30- days followed by a booster at 12 months can be used and is believed to have similar efficacy as the traditional schedule.[1]

    Efficacy

    The CDC reports that clinical trials found the following levels of protection against Hep A and Hep B one month after each dose:[2]

    A: 93.8%, 98.8%, 99.9%
    B: 30.8%, 78.2%, 98.5%

    GlaxoSmithKline claims that its studies found 70% of subjects had antibodies against hepatitis B a month after just the first dose, however.[3]

    See also

    References

    1. ↑ http://us.gsk.com/products/assets/us_twinrix.pdf
    2. ↑ "FDA approval for a combined hepatitis A and B vaccine". MMWR Morb. Mortal. Wkly. Rep. 50 (37): 806–7. September 2001. PMID 11785573.
    3. ↑ Twinrix Adult Vaccine, SPC from the eMC


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