Tre recombinase

Tre recombinase is an experimental enzyme that in lab tests has removed DNA inserted by HIV from infected cells.[1] The enzyme was derived from Cre recombinase through selective mutation for the purposes of identifying HIV markers, which are not bounded by loxP sites and therefore disallow attempts at Cre-Lox recombination.

References

  1. ↑ Sarkar, Indrani; Hauber, Ilona; Hauber, Joachim; Buchholz, Frank (2007). "HIV-1 proviral DNA excision using an evolved recombinase". Science. 316 (5833): 1912–15. doi:10.1126/science.1141453. PMID 17600219.
  • Minkel, JR (June 28, 2007). "Designer enzyme cuts HIV out of infected cells". Scientific American.
  • Hauber, Ilona; Hofmann-Sieber, Helga; Chemnitz, Jan; et al. (September 26, 2013). "Highly Significant Antiviral Activity of HIV-1 LTR-Specific Tre-Recombinase in Humanized Mice". PLoS Pathogens. doi:10.1371/journal.ppat.1003587.
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