MK-2048

MK-2048
	MK-2048
Clinical data
ATC code	none;
Legal status
Legal status	US: Investigational New Drug ;
Identifiers
	IUPAC name (6S)-2-[(3-chloro-4-fluorophenyl)methyl]-8-ethyl-9-hydroxy-N,6-dimethyl-1,10-dioxo-6,7-dihydropyrazino[3,4]pyrrolo[3,4-b]pyridazine-4-carboxamide;
CAS Number	869901-69-9 ;
PubChem CID	11554427;
ChemSpider	25058456;
UNII	LJ8U884TM5;
ChEMBL	CHEMBL1237018;
Chemical and physical data
Formula	C21H21ClFN5O4
Molar mass	461.87 g/mol
3D model (JSmol)	Interactive image;
	SMILES CCN1CC(N2C3=C(C(=O)C2=C1O)C(=O)N(N=C3C(=O)NC)CC4=CC(=C(C=C4)F)Cl)C;
	InChI InChI=1S/C21H21ClFN5O4/c1-4-26-8-10(2)28-16-14(18(29)17(28)21(26)32)20(31)27(25-15(16)19(30)24-3)9-11-5-6-13(23)12(22)7-11/h5-7,10,32H,4,8-9H2,1-3H3,(H,24,30)/t10-/m0/s1; Key:IOYLKNABOQYKKY-JTQLQIEISA-N;

MK-2048 is a second generation integrase inhibitor, intended to be used against HIV infection. It is superior to the first available integrase inhibitor, raltegravir, in that it inhibits the HIV enzyme integrase 4 times longer. It is being investigated for use as part of pre-exposure prophylaxis (PrEP).^[1]

It is being developed by Merck & Co.^[2]

References

↑ Keith Alcorn. Ralvetgravir shows potential for use as PrEP drug AIDSmap.com. 28 April 2009. Accessed 8 Nov 2009.
↑ Mark Mascolini. Merck Offers Unique Perspective on Second-Generation Integrase Inhibitor. 10th International Workshop on Clinical Pharmacology of HIV Therapy, April 15–17, 2009, Amsterdam. Accessed 8 Nov 2009.

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[1] Keith Alcorn. Ralvetgravir shows potential for use as PrEP drug AIDSmap.com. 28 April 2009. Accessed 8 Nov 2009.

[2] Mark Mascolini. Merck Offers Unique Perspective on Second-Generation Integrase Inhibitor. 10th International Workshop on Clinical Pharmacology of HIV Therapy, April 15–17, 2009, Amsterdam. Accessed 8 Nov 2009.

Clinical data
MK-2048
ATC code	none
Legal status
Legal status	US: Investigational New Drug
Identifiers
IUPAC name (6S)-2-[(3-chloro-4-fluorophenyl)methyl]-8-ethyl-9-hydroxy-N,6-dimethyl-1,10-dioxo-6,7-dihydropyrazino[3,4]pyrrolo[3,4-b]pyridazine-4-carboxamide
CAS Number	869901-69-9^Y
PubChem CID	11554427
ChemSpider	25058456
UNII	LJ8U884TM5
ChEMBL	CHEMBL1237018
Chemical and physical data
Formula	C₂₁H₂₁ClFN₅O₄
Molar mass	461.87 g/mol
3D model (JSmol)	Interactive image
SMILES CCN1CC(N2C3=C(C(=O)C2=C1O)C(=O)N(N=C3C(=O)NC)CC4=CC(=C(C=C4)F)Cl)C
InChI InChI=1S/C21H21ClFN5O4/c1-4-26-8-10(2)28-16-14(18(29)17(28)21(26)32)20(31)27(25-15(16)19(30)24-3)9-11-5-6-13(23)12(22)7-11/h5-7,10,32H,4,8-9H2,1-3H3,(H,24,30)/t10-/m0/s1 Key:IOYLKNABOQYKKY-JTQLQIEISA-N