Terpentedienyl-diphosphate synthase

Terpentedienyl-diphosphate synthase
Identifiers
EC number 5.5.1.15
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Terpentedienyl-diphosphate synthase (EC 5.5.1.15, terpentedienol diphosphate synthase, Cyc1, clerodadienyl diphosphate synthase) is an enzyme with systematic name terpentedienyl-diphosphate lyase (decyclizing).[1][2][3] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate terpentedienyl diphosphate

This enzyme requires Mg2+.

References

  1. ↑ Dairi T, Hamano Y, Kuzuyama T, Itoh N, Furihata K, Seto H (October 2001). "Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin". Journal of Bacteriology. 183 (20): 6085–94. doi:10.1128/jb.183.20.6085-6094.2001. PMC 99688. PMID 11567009.
  2. ↑ Hamano Y, Kuzuyama T, Itoh N, Furihata K, Seto H, Dairi T (October 2002). "Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin". The Journal of Biological Chemistry. 277 (40): 37098–104. doi:10.1074/jbc.m206382200. PMID 12138123.
  3. ↑ Eguchi T, Dekishima Y, Hamano Y, Dairi T, Seto H, Kakinuma K (July 2003). "A new approach for the investigation of isoprenoid biosynthesis featuring pathway switching, deuterium hyperlabeling, and 1H NMR spectroscopy. The reaction mechanism of a novel streptomyces diterpene cyclase". The Journal of Organic Chemistry. 68 (14): 5433–8. doi:10.1021/jo026728a. PMID 12839434.
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