Syntelic

Syntelic attachment occurs when both sister chromosomes are attached to a single spindle pole.[1][2]

Normal cell division distributes the genome equally between two daughter cells, with each chromosome attaching to an ovoid structure called the spindle. During the division process, errors commonly occur in attaching the chromosomes to the spindle, estimated to affect 86 to 90 percent of chromosomes.[3]

Such attachment errors are common during the early stages of spindle formation, but they are mostly corrected before the start of anaphase.[4] Successful cell division requires identification and correction of any dangerous errors before the cell splits in two.[3] If the syntelic attachment continues, it causes both sister chromatids to be segregated to a single daughter cell.[5]

Notes

  1. ↑ "Examining chromosome-microtubule attachment". Archived from the original on 3 September 2010.
  2. ↑ London, Nitobe; Biggins, Sue (1 November 2014). "Signalling dynamics in the spindle checkpoint response". Nature Reviews Molecular Cell Biology. 15 (11): 736–748. doi:10.1038/nrm3888. PMC 4283840. Retrieved 3 February 2017.
  3. 1 2 "Molecular forces are key to proper cell division". www.sciencedaily.com. University of Massachusetts Amherst. January 21, 2013. Retrieved 3 February 2017.
  4. ↑ "CELLS Interactive Glossary: Syntelic attachment". bioscience.jbpub.com. Jones and Bartlett Publishers. Retrieved 3 February 2017.
  5. ↑ Walczak, Claire E.; Cai, Shang; Khodjakov, Alexey (20 January 2010). "Mechanisms of chromosome behaviour during mitosis". Nature Reviews Molecular Cell Biology. 11: 91–102. doi:10.1038/nrm2832. PMC 2893392.


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