Succinylsulfathiazole

Succinylsulfathiazole
Clinical data
ATC code	A07AB04 (WHO) ;
Identifiers
	IUPAC name 4-oxo-4-({4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}amino)butanoic acid;
PubChem CID	5315;
UNII	RSS8647O4S;
KEGG	D07060 ;
ChEMBL	CHEMBL1484857;
ECHA InfoCard	100.003.765
Chemical and physical data
Formula	C13H13N3O5S2
Molar mass	355.38942 g/mol
3D model (JSmol)	Interactive image;
	SMILES OC(=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2nccs2;
(verify)

Succinylsulfathiazole is a sulfonamide. It is also spelled as succinylsulphathiazole. It is a white or yellow-white crystalline powder. It dissolves in aqueous solutions of alkali hydroxides and carbonates but is very slightly soluble in water.

It is classified as ultra long acting drug. About 95% of the drug remains in the intestine and only 5% is hydrolyzed, slowly, to Sulfathiazole and is absorbed.

The drug is used for its antibacterial activity in the GIT. The dose is 10g - 20g daily in divided doses.

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Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07)
Rehydration	Oral rehydration therapy
Intestinal anti-infectives	Antibiotics Amphotericin B Colistin Fidaxomicin Kanamycin Natamycin Neomycin Nystatin Paromomycin Polymyxin B Rifaximin Streptomycin Vancomycin Sulfonamides Phthalylsulfathiazole Succinylsulfathiazole Sulfaguanidine Nitrofuran Nifuroxazide Nifurzide Imidazole Miconazole Arsenical Acetarsol Oxyquinoline Broxyquinoline
Intestinal adsorbents	Charcoal Bismuth Pectin Kaolin Crospovidone Attapulgite Diosmectite
Antipropulsives (opioids)	Opium tincture (laudanum) Codeine Morphine Camphorated opium tincture (paregoric) crosses BBB: Diphenoxylate (Diphenoxylate/atropine) Difenoxin does not cross BBB: Eluxadoline Loperamide^#
Intestinal anti-inflammatory agents	corticosteroids acting locally Prednisolone^# Hydrocortisone Prednisone Betamethasone^# Tixocortol Budesonide Beclometasone antiallergic agents, excluding corticosteroids Cromoglicic acid Aminosalicylates Sulfasalazine Mesalazine Olsalazine Balsalazide
Antidiarrheal micro-organisms	Saccharomyces boulardii
Other antidiarrheals	Albumin tannate Ceratonia Crofelemer Octreotide Racecadotril
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

Clinical data

ATC code	A07AB04 (WHO)
Identifiers
IUPAC name 4-oxo-4-({4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}amino)butanoic acid
PubChem CID	5315
UNII	RSS8647O4S
KEGG	D07060^Y
ChEMBL	CHEMBL1484857
ECHA InfoCard	100.003.765
Chemical and physical data
Formula	C₁₃H₁₃N₃O₅S₂
Molar mass	355.38942 g/mol
3D model (JSmol)	Interactive image
SMILES OC(=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2nccs2
(verify)