Stratum corneum chymotryptic enzyme

Stratum corneum chymotryptic enzyme
Identifiers
EC number 3.4.21.117
CAS number 155215-90-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Stratum corneum chymotryptic enzyme (EC 3.4.21.117, kallikrein 7, SCCE, KLK7, PRSS6, hK7) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Cleavage of proteins with aromatic side chains in the P1 position

This enzyme has wide substrate specificity.

References

  1. ↑ Skytt, A., Strömqvist, M. and Egelrud, T. (1995). "Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme". Biochem. Biophys. Res. Commun. 211: 586–589. doi:10.1006/bbrc.1995.1853. PMID 7794273.
  2. ↑ Egelrud, T. (1993). "Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation". J. Invest. Dermatol. 101 (2): 200–204. doi:10.1111/1523-1747.ep12363804. PMID 8393902.
  3. ↑ Hansson, L., Strömqvist, M., Bäckman, A., Wallbrandt, P., Carlstein, A. and Egelrud, T. (1994). "Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase". J. Biol. Chem. 269 (30): 19420–19426. PMID 8034709.
  4. ↑ Yousef, G.M., Scorilas, A., Magklara, A., Soosaipillai, A. and Diamandis, E.P. (2000). "The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation". Gene. 254: 119–128. doi:10.1016/S0378-1119(00)00280-8. PMID 10974542.
  5. ↑ Vasilopoulos, Y., Cork, M.J., Murphy, R., Williams, H.C., Robinson, D.A., Duff, G.W., Ward, S.J. and Tazi-Ahnini, R. (2004). "Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis". J. Invest. Dermatol. 123: 62–66. doi:10.1111/j.0022-202X.2004.22708.x. PMID 15191543.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.