Stephen Tsang

Stephen H. Tsang
Native name 曾慶霖
Residence United States
Education Johns Hopkins University (B.S.), Columbia College of Physicians and Surgeons (M.D.-Ph.D.)
Known for Successfully treated preclinical models of Pde6a, Pde6b, Mfrp, and autosomal recessive bestrophinopathy retinopathies
Scientific career
Fields ophthalmology, genetics
Institutions Columbia University Medical Center

Stephen H. Tsang (Chinese: 曾慶霖; Pinyin: Zeng Qing-Lin) is an ophthalmologist and geneticist. He is currently an Associate Professor of Ophthalmology and an Associate Professor of Cell Biology and Pathology at Columbia University Medical Center in New York City, New York, in the United States.[1]

Tsang studies metabolic signaling in retinal diseases, as well as gene therapy and stem cell therapy to treat such diseases.[2][3][4][5] In 2010, Tsang led an international research team that used embryonic stem cells of mice to replace diseased retinal cells in mice with retinitis pigmentosa to restore sight.[6] In 2012, Tsang produced long term visual improvement in retinitis pigmentosa mouse models in two experiments, one using induced pluripotent stem cells and the other gene therapy.[7] In 2015, Tsang was among the leaders of a team which discovered a gene mutation that can cause achromatopsia.[1] In 2016, Tsang's team, in partnership with University of Iowa scientists, used the genome editing tool called CRISPR to repair a mutation that causes retinitis pigmentosa in patient derived stem cells.[8][9] In 2018, Tsang and his team created a new technique for CRISPR, restoring function in the retina of mice affected by retinitis pigmentosa.[3][10]

Biography

Tsang is of Cantonese descent and immigrated to the United States after high school, graduating college from Johns Hopkins University.[11] During college, Tsang trained in medical genetics under Professor Victor A. McKusick.[12] He obtained an M.D.-Ph.D. from the NIH-National Institute of General Medical Sciences Medical Scientist Training Program at Columbia University.[12] Tsang did his residency at Jules Stein Eye Institute/UCLA, and then he studied with Professors Alan C. Bird and Graham E. Holder, researching how to improve care of people suffering macular degeneration.[1] Tsang is the editor of two books on regenerative medicine and precision medicine.[13][14][15] He has authored over 280 peer reviewed articles, including articles published in Science and Journal of Clinical Investigation.[16]

Selected Honors

References

  1. 1 2 3 4 "Stephen H. Tsang, MD, PhD". Pathology. 2017-06-21. Retrieved 2018-07-11.
  2. ↑ "Scientists foresee fixes even for complicated forms of blindness". NBC News. Retrieved 2018-07-11.
  3. 1 2 3 "Genome Surgery for Eye Disease Moves Closer to Reality - American Academy of Ophthalmology". www.aao.org. Retrieved 2018-07-11.
  4. ↑ "Stephen Tsang | NYSTEM". stemcell.ny.gov. Retrieved 2018-07-11.
  5. ↑ [CUMC press office] (1 June 2015). New Color Blindness Cause Identified Finding Suggests Potential Therapeutic Targets. States News Service. Accessed November 2015. (subscription required)
  6. ↑ "Columbia University Medical Center Press Release". www.cumc.columbia.edu. Retrieved 2018-07-11.
  7. ↑ "Two Treatments for Retinitis Pigmentosa Move Closer to Clinical Trials - Columbia University Medical Center". Columbia University Medical Center. 2012-12-20. Retrieved 2018-07-11.
  8. ↑ "Combination of Stem Cells and Gene Modifying Tools Provide Path to Vision Repair | NYSTEM". stemcell.ny.gov. Retrieved 2018-07-11.
  9. ↑ Mullin, Emily. "CRISPR Used To Repair Blindness-Causing Gene Defect". Forbes. Retrieved 2018-07-19.
  10. ↑ "Columbia University Medical Center Press Release". www.cumc.columbia.edu. Retrieved 2018-07-11.
  11. ↑ "Stephen H. Tsang, MD, PhD". Institute of Genomic Medicine. Retrieved 2018-07-11.
  12. 1 2 "Columbia Ophthalmology". www.columbiaeye.org. Retrieved 2018-07-11.
  13. ↑ Precision Medicine, CRISPR, and Genome Engineering - Moving from Association to Biology and Therapeutics | Stephen Tsang | Springer.
  14. ↑ "Recent book publication edited by Dr. Stephen Tsang". Columbia Stem Cell Initiative - CSCI. 2017-12-05. Retrieved 2018-07-11.
  15. ↑ Stem Cell Biology and Regenerative Medicine in Ophthalmology | Stephen Tsang | Springer.
  16. ↑ pubmeddev. "tsang sh - PubMed - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-07-13.
  17. ↑ "Stein Eye Institute 50 Years of Vision: Patient Care" (PDF). UCLA Health.
  18. ↑ "Stephen H. Tsang, MD, PhD | Herbert Irving Comprehensive Cancer Center". cancer.columbia.edu. Retrieved 2018-07-13.
  19. ↑ "History | Association of University Professors of Ophthalmology". aupo.org. Retrieved 2018-07-13.
  20. ↑ "ARVO/Alcon Early Career Clinician-Scientist Research Awards" (PDF). ARVO Foundation.
  21. ↑ "Recipient history". arvo-prod.serverside.net. Retrieved 2018-07-13.
  22. ↑ "Stephen Tsang, MD PhD | Choroideremia Research Foundation". www.curechm.org. Retrieved 2018-07-13.
  23. ↑ "Member Directory". The American Society for Clinical Investigation.
  24. ↑ "Awards & Lectures". www.maculasociety.org. Retrieved 2018-07-13.
  25. ↑ "Credentials | Dr. Stephen H Tsang MD Reviews | New York, NY | Vitals.com". www.vitals.com. Retrieved 2018-07-16.
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