Spermatogenesis associated 13

SPATA13
Identifiers
Aliases	SPATA13, ARHGEF29, ASEF2, spermatogenesis associated 13
External IDs	MGI: 104838 HomoloGene: 19482 GeneCards: SPATA13
Gene location (Human)
Chr.	Chromosome 13 (human)[1]
End	24,307,074 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	60,764,556 bp[2]
Gene ontology
Molecular function	• Rac guanyl-nucleotide exchange factor activity; • Rho guanyl-nucleotide exchange factor activity; • protein binding; • guanyl-nucleotide exchange factor activity; • identical protein binding;
Cellular component	• cytoplasm; • filopodium; • ruffle membrane; • plasma membrane; • cell projection; • membrane; • lamellipodium; • nucleoplasm; • cytosol;
Biological process	• filopodium assembly; • regulation of Rho protein signal transduction; • regulation of cell migration; • cell migration; • lamellipodium assembly;
	Sources:Amigo / QuickGO
Orthologs
	221178
	219140
	ENSG00000182957
	ENSMUSG00000021990
	Q96N96
	Q5DU57
NM_001166271; NM_001286792; NM_001286793; NM_001286794; NM_001286795;
	NM_153023
	NM_001033272; NM_001310594
NP_001159743; NP_001273721; NP_001273722; NP_001273723; NP_001273724;
	NP_694568; NP_694568.1
	NP_001028444; NP_001297523
	Wikidata
View/Edit Human	View/Edit Mouse

Spermatogenesis associated 13 is a protein that in humans is encoded by the SPATA13 gene. ^[5]

References

Kawasaki Y, Sagara M, Shibata Y, Shirouzu M, Yokoyama S, Akiyama T (December 2007). "Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42". Oncogene. 26 (55): 7620–267. doi:10.1038/sj.onc.1210574. PMID 17599059.
Sagara M, Kawasaki Y, Iemura SI, Natsume T, Takai Y, Akiyama T (March 2009). "Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration". Oncogene. 28 (10): 1357–65. doi:10.1038/onc.2008.478. PMID 19151759.
Ding H, Xu Y, Bao X, Wang X, Cui G, Wang W, Hui R, Wang DW (January 2010). "Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke". Stroke. 41 (1): 177–80. doi:10.1161/STROKEAHA.109.567099. PMID 19910543.
Bristow JM, Sellers MH, Majumdar D, Anderson B, Hu L, Webb DJ (December 2009). "The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration". J. Cell Sci. 122 (Pt 24): 4535–46. doi:10.1242/jcs.053728. PMC 2787464. PMID 19934221.
Jean L, Majumdar D, Shi M, Hinkle LE, Diggins NL, Ao M, Broussard JA, Evans JC, Choma DP, Webb DJ (December 2013). "Activation of Rac by Asef2 promotes myosin II-dependent contractility to inhibit cell migration on type I collagen". J. Cell Sci. 126 (Pt 24): 5585–97. doi:10.1242/jcs.131060. PMC 3860307. PMID 24144700.

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