Somatic recombination

Somatic recombination, as opposed to the genetic recombination that occurs in meiosis, is an alteration of the DNA of a somatic cell that is inherited by its daughter cells. The term is usually reserved for large-scale alterations of DNA such as chromosomal translocations and deletions and not applied to point mutations. Somatic recombination occurs physiologically in the assembly of the B cell receptor and T-cell receptor genes (V(D)J recombination),[1] as well as in the class switching of immunoglobulins.[2] Somatic recombination is also important in the process of carcinogenesis.[3]

References

  1. ↑ Gellert M (1992) Molecular analysis of V(D)J recombination. Annu Rev Genet 26:425–46. PMID 1482120
  2. ↑ Hein K, Lorenz MG, Siebenkotten G, et al. (1998) Processing of switch transcripts is required for targeting of antibody class switch recombination. J Exp Med 188:2369–74. PMID 9858523
  3. ↑ Ramel C, Cederberg H, Magnusson J, et al. (1996) Somatic recombination, gene amplification and cancer. Mutat Res 353:85–107. PMID 8692194


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