Small Cajal body specific RNA 16

Small Cajal body specific RNA 16
Predicted secondary structure and sequence conservation of SCARNA16
Identifiers
Symbol SCARNA16
Alt. Symbols snoACA47
Rfam RF00424
Other data
RNA type Gene; snRNA; snoRNA; scaRNA
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000275
PDB structures PDBe

Small Cajal body specific RNA 16 (also known as SCARNA16 or ACA47) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U1 spliceosomal RNA.

scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1]

ACA47 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, the conserved H/ACA-box motifs and is found associated with GAR1.[2] ACA47 is predicted to guide the pseudouridylation of residue U5 of the U1 spliceosomal snRNA.[3]

References

  1. ↑ Darzacq, X; Jady BE; Verheggen C; Kiss AM; Bertrand E; Kiss T (2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". EMBO J. 21 (11): 2746&ndash, 2756. doi:10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.
  2. ↑ Kiss, Arnold M.; Jády, Beáta E.; Bertrand, Edouard; Kiss, Tamás (2004). "Human Box H/ACA Pseudouridylation Guide RNA Machinery". Molecular and Cellular Biology. 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
  3. ↑ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Supplement 1: Database Issue): D158–D162. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.


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