SERPINB7

SERPINB7
Identifiers
AliasesSERPINB7, MEGSIN, PPKN, TP55, serpin family B member 7
External IDsMGI: 2151053 HomoloGene: 68363 GeneCards: SERPINB7
Gene location (Human)
Chr.Chromosome 18 (human)[1]
Band18q21.33Start63,752,935 bp[1]
End63,805,376 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8710

116872

Ensembl

ENSG00000166396

ENSMUSG00000067001

UniProt

O75635

Q9D695

RefSeq (mRNA)

NM_001040147
NM_001261830
NM_001261831
NM_003784

NM_027548

RefSeq (protein)

NP_001035237
NP_001248759
NP_001248760
NP_003775

NP_081824

Location (UCSC)Chr 18: 63.75 – 63.81 MbChr 1: 107.4 – 107.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serpin B7 is a protein that in humans is encoded by the SERPINB7 gene.[5]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166396 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067001 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7".

Further reading

  • Tsujimoto M, Tsuruoka N, Ishida N, et al. (1997). "Purification, cDNA cloning, and characterization of a new serpin with megakaryocyte maturation activity". J. Biol. Chem. 272 (24): 15373–80. doi:10.1074/jbc.272.24.15373. PMID 9182567.
  • Miyata T, Nangaku M, Suzuki D, et al. (1998). "A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy". J. Clin. Invest. 102 (4): 828–36. doi:10.1172/JCI2450. PMC 508946. PMID 9710452.
  • Inagi R, Miyata T, Suzuki D, et al. (2001). "Specific tissue distribution of megsin, a novel serpin, in the glomerulus and its up-regulation in IgA nephropathy". Biochem. Biophys. Res. Commun. 286 (5): 1098–106. doi:10.1006/bbrc.2001.5509. PMID 11527413.
  • Inagi R, Miyata T, Imasawa T, et al. (2003). "Mesangial cell-predominant gene, megsin". Nephrol. Dial. Transplant. 17 Suppl 9: 32–3. doi:10.1093/ndt/17.suppl_9.32. PMID 12386281.
  • Inagi R, Miyata T, Nangaku M, et al. (2003). "Transcriptional regulation of a mesangium-predominant gene, megsin". J. Am. Soc. Nephrol. 13 (11): 2715–22. doi:10.1097/01.ASN.0000033507.32175.FA. PMID 12397041.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Li YJ, Du Y, Li CX, et al. (2004). "Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene". J. Am. Soc. Nephrol. 15 (7): 1739–43. doi:10.1097/01.ASN.0000130858.00688.46. PMID 15213261.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Inagi R, Nangaku M, Usuda N, et al. (2005). "Novel serpinopathy in rat kidney and pancreas induced by overexpression of megsin". J. Am. Soc. Nephrol. 16 (5): 1339–49. doi:10.1681/ASN.2004070600. PMID 15788472.
  • Xia Y, Li Y, Du Y, et al. (2006). "Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy". Nephrol. Dial. Transplant. 21 (6): 1570–4. doi:10.1093/ndt/gfk096. PMID 16431886.
  • Xia YF, Huang S, Li X, et al. (2006). "A family-based association study of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in a Chinese population". Clin. Nephrol. 65 (3): 153–9. doi:10.5414/cnp65153. PMID 16550745.

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