Retrotope

Retrotope, Inc. commercialises the idea that fortifying food with heavy isotopes^[2] protects living cells by making bonds within the delicate molecules inside and around cells harder to break and the cells less prone to damage. Founded in 2006 by a team of entrepreneurs and scientists including Dr Charles Cantor and Dr Robert Molinari using seed funding from private investors, Retrotope is developing a non-antioxidant approach to preventing lipid peroxidation, a detrimental factor in mitochondrial, neuronal and retinal diseases. The company employs the virtual business model^[3] and works in scientific collaboration with more than 80 research groups in universities worldwide.^[4]

Development

Retrotope's drug platform, deuterium stabilized polyunsaturated fatty acids (PUFA), prevents lipid peroxidation damage from propagating, rapidly stopping the toxic chain reaction at its source. Because the fatty acids in mitochondrial and cellular membranes turn over rapidly, the dietary substitution of stabilized fatty acids creates cells fortified against damage due to kinetic isotope effect. 11,11-D2-ethyl linoleate suppresses lipid peroxidation even at relatively low levels of incorporation into membranes.^[5] In 2010 Retrotope found that it more than 150 times increases the resistance of the yeast to oxidative stress,^[6][7] later it was shown to be effective in an animal model of Alzheimer's disease.^[8] A June 2018 study found that a diet of D-PUFA was shown to significantly decrease F2-isoprostanes (a cerebrospinal fluid found in elevated amounts in Huntington's disease) when fed to one-month old mice over the course of five months.^[9] These findings caused discussion in popular science press about the use of deuterated nutrients against ageing,^[10] but the most promising direction of further development was towards rare neurodegenerative disorders in which oxidative damage plays a part.

Clinical trials

The first deuterated PUFA made and studied by Retrotope, 11,11-D2-ethyl linoleate, has become the first Retrotope's drug RT001 that was taken into the clinic. It has passed Phase I/II clinical trial for the treatment of Freiderich's ataxia, reaching statistical significance in, and displaying strong correlations between several endpoint measurements.^[11]

In 2017 FDA granted RT001 orphan drug designation in the treatment of phospholipase 2G6-associated neurodegeneration (PLAN).^[12] A Phase II open-label clinical study for long-term evaluation of efficacy, safety, tolerability, and pharmacokinetics of RT001 in the treatment of Infantile Neuroaxonal Dystrophy started in the Summer 2018.^[13]

Other clinical use

After a petition for access filed by investigators at major medical centers, in 2018 RT001 was given to a patient with ALS under a "compassionate use" scheme sponsored by Retrotope.^[14]

References