Regulator of cell cycle RGCC

RGCC
Identifiers
Aliases	RGCC, C13orf15, RGC-32, RGC32, bA157L14.2, regulator of cell cycle
External IDs	MGI: 1913464 HomoloGene: 8544 GeneCards: RGCC
Gene location (Human)
Chr.	Chromosome 13 (human)[1]
End	41,470,882 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	79,301,645 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• R-SMAD binding; • protein kinase activator activity; • protein binding; • protein kinase binding;
Cellular component	• cytoplasm; • centrosome; • microtubule organizing center; • cytoskeleton; • cell nucleus; • cytosol; • nucleolus;
Biological process	• positive regulation of collagen biosynthetic process; • mitotic cell cycle arrest; • positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; • negative regulation of blood vessel endothelial cell migration; • negative regulation of cell-cell adhesion mediated by cadherin; • complement activation; • positive regulation of cytokine secretion; • positive regulation of extracellular matrix assembly; • positive regulation of sequence-specific DNA binding transcription factor activity; • negative regulation of mitotic cell cycle phase transition; • positive regulation of epithelial to mesenchymal transition; • positive regulation of extracellular matrix constituent secretion; • regulation of cell cycle; • negative regulation of endothelial cell proliferation; • positive regulation of endothelial cell apoptotic process; • positive regulation of gene expression; • negative regulation of cytokine secretion; • positive regulation of DNA biosynthetic process; • negative regulation of angiogenesis; • cell cycle; • fibroblast activation; • negative regulation of exit from mitosis; • positive regulation of mitotic nuclear division; • cellular response to hypoxia; • negative regulation of fibroblast growth factor production; • positive regulation of stress fiber assembly; • positive regulation of transcription from RNA polymerase II promoter; • negative regulation of cell proliferation; • positive regulation of cell cycle arrest; • activation of protein kinase activity; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
	Sources:Amigo / QuickGO
Orthologs
	28984
	66214
	ENSG00000102760
	ENSMUSG00000022018
	Q9H4X1
	Q9DBX1
	NM_014059
	NM_025427
	NP_054778
	NP_079703
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of cell cycle RGCC (RGCC) also known as response gene to complement 32 protein (RGC-32) is a protein that in humans is encoded by the RGCC gene.^[5]^[6]^[7]

Function

This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102760 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022018 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Saigusa K, Imoto I, Tanikawa C, Aoyagi M, Ohno K, Nakamura Y, Inazawa J (Feb 2007). "RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest". Oncogene. 26 (8): 1110–21. doi:10.1038/sj.onc.1210148. PMID 17146433.
↑ Huang WY, Li ZG, Rus H, Wang X, Jose PA, Chen SY (Mar 2009). "RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells". J Biol Chem. 284 (14): 9426–32. doi:10.1074/jbc.M900039200. PMC 2666595. PMID 19158077.
1 2 "Entrez Gene: RGC32 response gene to complement 32".

Fosbrink M, Niculescu F, Rus H (2005). "The role of c5b-9 terminal complement complex in activation of the cell cycle and transcription". Immunol. Res. 31 (1): 37–46. doi:10.1385/IR:31:1:37. PMID 15591621.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Badea TC, Niculescu FI, Soane L, et al. (1998). "Molecular cloning and characterization of RGC-32, a novel gene induced by complement activation in oligodendrocytes". J. Biol. Chem. 273 (41): 26977–81. doi:10.1074/jbc.273.41.26977. PMID 9756947.
Badea T, Niculescu F, Soane L, et al. (2002). "RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase". J. Biol. Chem. 277 (1): 502–8. doi:10.1074/jbc.M109354200. PMID 11687586.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Fosbrink M, Cudrici C, Niculescu F, et al. (2005). "Overexpression of RGC-32 in colon cancer and other tumors". Exp. Mol. Pathol. 78 (2): 116–22. doi:10.1016/j.yexmp.2004.11.001. PMID 15713436.
Tanaka T, Takada H, Nomura A, et al. (2005). "Distinct gene expression patterns of peripheral blood cells in hyper-IgE syndrome". Clin. Exp. Immunol. 140 (3): 524–31. doi:10.1111/j.1365-2249.2005.02805.x. PMC 1809394. PMID 15932515.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000102760 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022018 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid17146433-5] Saigusa K, Imoto I, Tanikawa C, Aoyagi M, Ohno K, Nakamura Y, Inazawa J (Feb 2007). "RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest". Oncogene. 26 (8): 1110–21. doi:10.1038/sj.onc.1210148. PMID 17146433.

[pmid19158077-6] Huang WY, Li ZG, Rus H, Wang X, Jose PA, Chen SY (Mar 2009). "RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells". J Biol Chem. 284 (14): 9426–32. doi:10.1074/jbc.M900039200. PMC 2666595. PMID 19158077.

[entrez-7] 1 2 "Entrez Gene: RGC32 response gene to complement 32".

Regulator of cell cycle RGCC

Function

References

Further reading