RMI1

RMI1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRMI1, BLAP75, C9orf76, FAAP75, RecQ mediated genome instability 1
External IDsMGI: 1921636 HomoloGene: 41601 GeneCards: RMI1
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q21.32Start83,980,711 bp[1]
End84,004,074 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

80010

74386

Ensembl

ENSG00000178966

ENSMUSG00000035367

UniProt

Q9H9A7

Q9D4G9

RefSeq (mRNA)

NM_024945
NM_001358291
NM_001358292
NM_001358293
NM_001358294

NM_001168248
NM_028904

RefSeq (protein)

NP_079221
NP_001345220
NP_001345221
NP_001345222
NP_001345223

NP_001161720
NP_083180

Location (UCSC)Chr 9: 83.98 – 84 MbChr 13: 58.4 – 58.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RecQ-mediated genome instability protein 1 is a protein that in humans is encoded by the RMI1 gene.[5][6]

Meiosis

During meiosis in budding yeast Saccharomyces cerevisiae, TOP3 (a type I topoisomerase) and its accessory factor RMI1 form a heterodimer that functions to allow passage of one DNA single strand through another. The TOP3-RMI1 heterodimer associates with Sgs1 (Bloom helicase ortholog) to form a complex that catalyzes dissolution of double Holliday junctions.[7] Furthermore, the TOP3-RMI1 heterodimer participates in all meiotic recombination functions associated with Sgs1, most significantly as an early recombination intermediate chaperone, promoting regulated crossover and non-crossover recombination and preventing accumulation of aberrant recombination intermediates.[8] In particular, the TOP3-RMI1–SGS1 complex promotes early formation of non-crossover recombinants during meiosis.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000178966 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035367 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Yin J, Sobeck A, Xu C, Meetei AR, Hoatlin M, Li L, Wang W (May 2005). "BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity". EMBO J. 24 (7): 1465–76. doi:10.1038/sj.emboj.7600622. PMC 1142546. PMID 15775963.
  6. ↑ "Entrez Gene: RMI1 RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)".
  7. ↑ Bizard AH, Hickson ID (2014). "The dissolution of double Holliday junctions". Cold Spring Harb Perspect Biol. 6 (7): a016477. doi:10.1101/cshperspect.a016477. PMC 4067992. PMID 24984776.
  8. 1 2 Kaur H, De Muyt A, Lichten M (2015). "Top3-Rmi1 DNA single-strand decatenase is integral to the formation and resolution of meiotic recombination intermediates". Mol. Cell. 57 (4): 583–94. doi:10.1016/j.molcel.2015.01.020. PMC 4338413. PMID 25699707.

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Meetei AR, de Winter JP, Medhurst AL, et al. (2003). "A novel ubiquitin ligase is deficient in Fanconi anemia". Nat. Genet. 35 (2): 165–70. doi:10.1038/ng1241. PMID 12973351.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wu L, Bachrati CZ, Ou J, et al. (2006). "BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates". Proc. Natl. Acad. Sci. U.S.A. 103 (11): 4068–73. doi:10.1073/pnas.0508295103. PMC 1449647. PMID 16537486.
  • Raynard S, Bussen W, Sung P (2006). "A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75". J. Biol. Chem. 281 (20): 13861–4. doi:10.1074/jbc.C600051200. PMID 16595695.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Bussen W, Raynard S, Busygina V, et al. (2007). "Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex". J. Biol. Chem. 282 (43): 31484–92. doi:10.1074/jbc.M706116200. PMID 17728255.
  • Broberg K, Höglund M, Gustafsson C, et al. (2008). "Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk of AML/MDS and malignant melanoma". Cancer Lett. 258 (1): 38–44. doi:10.1016/j.canlet.2007.08.005. PMID 17900800.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.