REG3A

REG3A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesREG3A, HIP, HIP/PAP, INGAP, PAP, PAP-H, PAP1, PBCGF, REG-III, REG3, regenerating family member 3 alpha
External IDsMGI: 97478 HomoloGene: 130506 GeneCards: REG3A
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p12Start79,157,003 bp[1]
End79,159,753 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5068

18489

Ensembl

ENSG00000172016

ENSMUSG00000071356

UniProt

Q06141

P35230

RefSeq (mRNA)

NM_138938
NM_002580
NM_138937

NM_011036

RefSeq (protein)

NP_002571
NP_620354
NP_620355

NP_035166

Location (UCSC)Chr 2: 79.16 – 79.16 MbChr 6: 78.37 – 78.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Regenerating islet-derived protein 3 alpha (or Regenerating islet-derived protein III-alpha) formerly known as HIP/PAP (Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-Associated Protein) and peptide 23[5] is a protein that in humans is encoded by the REG3A gene.[6][7]

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. Multiple alternatively spliced transcript variants encoding the same protein have been described for this gene but the full length nature of some transcripts is not yet known.[7]

Reg3A (UniProt Q0614 1) is a bactericidal C-type lectin that is constitutively produced in the intestine that has antibacterial properties against Gram-positive bacteria. Bacterial killing is mediated by binding to surface-exposed carbohydrate moieties of bacterial peptidoglycan.[8][9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000172016 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071356 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Chakraborty C, Sharma S, Katsumata N, Murphy LJ, Schroedter IC, Robertson MC, Shiu RP, Friesen HG (Jun 1995). "Plasma clearance, tissue uptake and expression of pituitary peptide 23/pancreatitis-associated protein in the rat". Journal of Endocrinology. PMID 7636430.
  6. ↑ Dusetti NJ, Frigerio JM, Fox MF, Swallow DM, Dagorn JC, Iovanna JL (Jun 1994). "Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene". Genomics. 19 (1): 108–14. doi:10.1006/geno.1994.1019. PMID 8188210.
  7. 1 2 "Entrez Gene: REG3A regenerating islet-derived 3 alpha".
  8. ↑ Cash, Heather L.; Whitham, Cecilia V.; Behrendt, Cassie L.; Hooper, Lora V. (2006-08-25). "Symbiotic bacteria direct expression of an intestinal bactericidal lectin". Science. 313 (5790): 1126–1130. doi:10.1126/science.1127119. ISSN 1095-9203. PMC 2716667. PMID 16931762.
  9. ↑ Vaishnava, Shipra; Yamamoto, Miwako; Severson, Kari M.; Ruhn, Kelly A.; Yu, Xiaofei; Koren, Omry; Ley, Ruth; Wakeland, Edward K.; Hooper, Lora V. (2011-10-14). "The antibacterial lectin RegIIIγ promotes the spatial segregation of microbiota and host in the intestine". Science. 334 (6053): 255–258. doi:10.1126/science.1209791. ISSN 0036-8075. PMC 3321924. PMID 21998396.

Further reading

  • Lasserre C, Christa L, Simon MT, et al. (1992). "A novel gene (HIP) activated in human primary liver cancer". Cancer Res. 52 (18): 5089–95. PMID 1325291.
  • Orelle B, Keim V, Masciotra L, et al. (1993). "Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases". J. Clin. Invest. 90 (6): 2284–91. doi:10.1172/JCI116115. PMC 443380. PMID 1469087.
  • Itoh T, Teraoka H (1993). "Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP)". Biochim. Biophys. Acta. 1172 (1–2): 184–6. doi:10.1016/0167-4781(93)90290-t. PMID 7679928.
  • Itoh T, Sawabu N, Motoo Y, et al. (1995). "The human pancreatitis-associated protein (PAP)-encoding gene generates multiple transcripts through alternative use of 5' exons". Gene. 155 (2): 283–7. doi:10.1016/0378-1119(94)00799-X. PMID 7721106.
  • Lasserre C, Simon MT, Ishikawa H, et al. (1994). "Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer". Eur. J. Biochem. 224 (1): 29–38. doi:10.1111/j.1432-1033.1994.tb19991.x. PMID 8076648.
  • Christa L, Carnot F, Simon MT, et al. (1997). "HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells". Am. J. Physiol. 271 (6 Pt 1): G993–1002. PMID 8997243.
  • Rafaeloff R, Pittenger GL, Barlow SW, et al. (1997). "Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters". J. Clin. Invest. 99 (9): 2100–9. doi:10.1172/JCI119383. PMC 508040. PMID 9151782.
  • Bödeker H, Keim V, Fiedler F, et al. (2000). "PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha". Mol. Cell Biol. Res. Commun. 2 (3): 150–4. doi:10.1006/mcbr.1999.0166. PMID 10662590.
  • Graf R, Schiesser M, Scheele GA, et al. (2001). "A family of 16-kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation". J. Biol. Chem. 276 (24): 21028–38. doi:10.1074/jbc.M010717200. PMID 11278730.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Simon MT, Pauloin A, Normand G, et al. (2003). "HIP/PAP stimulates liver regeneration after partial hepatectomy and combines mitogenic and anti-apoptotic functions through the PKA signaling pathway". FASEB J. 17 (11): 1441–50. doi:10.1096/fj.02-1013com. PMID 12890698.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Lieu HT, Batteux F, Simon MT, et al. (2005). "HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice". Hepatology. 42 (3): 618–26. doi:10.1002/hep.20845. PMID 16116631.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Cash HL, Whitham CV, Behrendt CL, Hooper LV (2006). "Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin". Science. 313 (5790): 1126–30. doi:10.1126/science.1127119. PMC 2716667. PMID 16931762.
  • Ho MR, Lou YC, Lin WC, et al. (2006). "Human pancreatitis-associated protein forms fibrillar aggregates with a native-like conformation". J. Biol. Chem. 281 (44): 33566–76. doi:10.1074/jbc.M604513200. PMID 16963458.


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