Plasmepsin I
| Plasmepsin I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.23.38 | ||||||||
| CAS number | 180189-87-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Plasmepsin I (EC 3.4.23.38, aspartic hemoglobinase I, PFAPG, malaria aspartic hemoglobinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of the -Phe33-Leu- bond in the alpha-chain of hemoglobin, leading to denaturation of the molecule
This enzyme is present in the malaria organism, Plasmodium.
References
- ↑ Goldberg, D.E.; Slater, A.F.G.; Beavis, R.; Chait, B.; Cerami, A.; Henderson, G.B. (1991). "Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease". J. Exp. Med. 173 (4): 961–969. doi:10.1084/jem.173.4.961. PMC 2190804. PMID 2007860.
- ↑ Francis, S.E.; Gluzman, I.Y.; Oksman, A.; Knickerbocker, A.; Mueller, R.; Bryant, M.L.; Sherman, D.R.; Russell, D.G.; Goldberg, D.E. (1994). "Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase". EMBO J. 13 (2): 306–317. PMC 394809. PMID 8313875.
- ↑ Gluzman, I.Y.; Francis, S.E.; Oksman, A.; Smith, C.E.; Duffin, K.L.; Goldberg, D.E. (1994). "Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway". J. Clin. Invest. 93: 1602–1608. doi:10.1172/JCI117140. PMC 294190. PMID 8163662.
External links
- Plasmepsin+I at the US National Library of Medicine Medical Subject Headings (MeSH)
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