PSMA8

PSMA8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4R3O, 4R67
Identifiers
Aliases	PSMA8, PSMA7L, proteasome subunit alpha 8
External IDs	MGI: 1920927 HomoloGene: 2086 GeneCards: PSMA8
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q11.2 Start 26,133,852 bp[1] End 26,193,355 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 14,706,151 bp[2] End 14,762,299 bp[2]
Gene ontology Molecular function • endopeptidase activity • peptidase activity • threonine-type endopeptidase activity • hydrolase activity Cellular component • cytoplasm • cytosol • spermatoproteasome complex • proteasome complex • extracellular exosome • cell nucleus • proteasome core complex • proteasome core complex, alpha-subunit complex Biological process • regulation of cellular amino acid metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of mRNA stability • ubiquitin-dependent protein catabolic process • positive regulation of canonical Wnt signaling pathway • protein polyubiquitination • stimulatory C-type lectin receptor signaling pathway • tumor necrosis factor-mediated signaling pathway • MAPK cascade • proteolysis • Fc-epsilon receptor signaling pathway • NIK/NF-kappaB signaling • anaphase-promoting complex-dependent catabolic process • proteolysis involved in cellular protein catabolic process • T cell receptor signaling pathway • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • negative regulation of canonical Wnt signaling pathway • Wnt signaling pathway, planar cell polarity pathway • proteasome-mediated ubiquitin-dependent protein catabolic process • negative regulation of G2/M transition of mitotic cell cycle • protein deubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • transmembrane transport • regulation of transcription from RNA polymerase II promoter in response to hypoxia • post-translational protein modification • regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	143471	73677
Ensembl	ENSG00000154611	ENSMUSG00000036743
UniProt	Q8TAA3	Q9CWH6
RefSeq (mRNA)	NM_001025096 NM_001025097 NM_001308188 NM_144662	NM_001163609 NM_001360823
RefSeq (protein)	NP_001020267 NP_001020268 NP_001295117 NP_653263	NP_001157081 NP_001347752
Location (UCSC)	Chr 18: 26.13 – 26.19 Mb	Chr 18: 14.71 – 14.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Proteasome subunit alpha 8 also known as proteasome subunit alpha type-7-like is a protein that in humans is encoded by the PSMA8 gene.^[5] Proteasome subunit alpha 8 is a component of the sperm specific proteasome.^[6]

References