POLR3C

POLR3C
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLR3C, RPC3, RPC62, polymerase (RNA) III subunit C, RNA polymerase III subunit C
External IDsMGI: 1921664 HomoloGene: 38185 GeneCards: POLR3C
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q21.1Start145,824,088 bp[1]
End145,842,505 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10623

74414

Ensembl

ENSG00000186141

ENSMUSG00000028099

UniProt

Q9BUI4

Q9D483

RefSeq (mRNA)

NM_001303456
NM_006468

NM_028925

RefSeq (protein)

NP_001290385
NP_006459

NP_083201

Location (UCSC)Chr 1: 145.82 – 145.84 MbChr 3: 96.71 – 96.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene.[5][6][7]

Interactions

POLR3C has been shown to interact with GTF3C4.[8][9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000186141 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028099 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Wang Z, Roeder RG (Jun 1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes Dev. 11 (10): 1315–26. doi:10.1101/gad.11.10.1315. PMID 9171375.
  6. ↑ Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Oct 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits". Mol Cell Biol. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
  7. ↑ "Entrez Gene: POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)".
  8. ↑ Hsieh, Y J; Wang Z; Kovelman R; Roeder R G (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. UNITED STATES. 19 (7): 4944–52. ISSN 0270-7306. PMC 84305. PMID 10373544.
  9. ↑ Hsieh, Y J; Kundu T K; Wang Z; Kovelman R; Roeder R G (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. UNITED STATES. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. ISSN 0270-7306. PMC 84812. PMID 10523658.
  10. ↑ Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

Further reading

  • Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hsieh YJ, Wang Z, Kovelman R, Roeder RG (1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. PMC 84305. PMID 10373544.
  • Hsieh YJ, Kundu TK, Wang Z, et al. (1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
  • Kuwana M, Kimura K, Kawakami Y (2002). "Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay". Arthritis Rheum. 46 (10): 2742–7. doi:10.1002/art.10521. PMID 12384934.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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