PITPNM1

PITPNM1
Identifiers
AliasesPITPNM1, DRES9, NIR2, PITPNM, RDGB, RDGB1, RDGBA, RDGBA1, Rd9, phosphatidylinositol transfer protein membrane associated 1
External IDsMGI: 1197524 HomoloGene: 3608 GeneCards: PITPNM1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.2Start67,491,768 bp[1]
End67,506,263 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9600

18739

Ensembl

ENSG00000110697

n/a

UniProt

O00562

O35954

RefSeq (mRNA)

NM_001130848
NM_004910

NM_001136078
NM_008851

RefSeq (protein)

NP_001124320
NP_004901

NP_032877

Location (UCSC)Chr 11: 67.49 – 67.51 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Membrane-associated phosphatidylinositol transfer protein 1 is a protein that in humans is encoded by the PITPNM1 gene.[4][5]

Function

PITPNM1 belongs to a family of proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein.[supplied by OMIM][5]

It was found that aggressive metastasized cancer cells produced more of the PITPNC1 protein. In contrast, tumor cells that had not spread had lower expression of PITPNC1. Studies reveal that PITPNC1 promotes malignant secretion by binding Golgi-resident PI4P and localizing RAB1B to the Golgi. RAB1B localization to the Golgi allows for the recruitment of GOLPH3 (Golgi phosphoprotein 3), which facilitates Golgi extension and enhanced vesicular release. PITPNC1-mediated vesicular release drives metastasis by increasing the secretion of pro-invasive and pro-angiogenic mediators HTRA1, MMP1, FAM3C, PDGFA, and ADAM10.[6]

Interactions

PITPNM1 has been shown to interact with PTK2B.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000110697 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Mouse PubMed Reference:".
  4. ↑ Rubboli F, Bulfone A, Bogni S, Marchitiello A, Zollo M, Borsani G, Ballabio A, Banfi S (1997). "A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms". Genes Funct. 1 (3): 205–13. doi:10.1046/j.1365-4624.1997.00015.x. PMID 9680295.
  5. 1 2 "Entrez Gene: PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1".
  6. ↑ Halberg N, Sengelaub CA, Navrazhina K, Molina H, Uryu K, Tavazoie SF (2016). "PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion". Cancer Cell. 29 (3): 339–353. doi:10.1016/j.ccell.2016.02.013. PMID 26977884.
  7. ↑ Lev S, Hernandez J, Martinez R, Chen A, Plowman G, Schlessinger J (Mar 1999). "Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein". Mol. Cell. Biol. 19 (3): 2278–88. doi:10.1128/mcb.19.3.2278. PMC 84020. PMID 10022914.

Further reading

  • Vihtelic TS, Hyde DR, O'Tousa JE (1991). "Isolation and characterization of the Drosophila retinal degeneration B (rdgB) gene". Genetics. 127 (4): 761–8. PMC 1204403. PMID 1903119.
  • Aikawa Y, Hara H, Watanabe T (1997). "Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene". Biochem. Biophys. Res. Commun. 236 (3): 559–64. doi:10.1006/bbrc.1997.7009. PMID 9245688.
  • Tian D, Litvak V, Toledo-Rodriguez M, Carmon S, Lev S (2002). "Nir2, a novel regulator of cell morphogenesis". Mol. Cell. Biol. 22 (8): 2650–62. doi:10.1128/MCB.22.8.2650-2662.2002. PMC 133726. PMID 11909959.
  • Litvak V, Tian D, Carmon S, Lev S (2002). "Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis". Mol. Cell. Biol. 22 (14): 5064–75. doi:10.1128/MCB.22.14.5064-5075.2002. PMC 139767. PMID 12077336.
  • Litvak V, Shaul YD, Shulewitz M, Amarilio R, Carmon S, Lev S (2002). "Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain". Curr. Biol. 12 (17): 1513–8. doi:10.1016/S0960-9822(02)01107-7. PMID 12225667.
  • Litvak V, Argov R, Dahan N, Ramachandran S, Amarilio R, Shainskaya A, Lev S (2004). "Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion". Mol. Cell. 14 (3): 319–30. doi:10.1016/S1097-2765(04)00214-X. PMID 15125835.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Amarilio R, Ramachandran S, Sabanay H, Lev S (2005). "Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction". J. Biol. Chem. 280 (7): 5934–44. doi:10.1074/jbc.M409566200. PMID 15545272.
  • Ocaka L, Spalluto C, Wilson DI, Hunt DM, Halford S (2005). "Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3". Cytogenet. Genome Res. 108 (4): 293–302. doi:10.1159/000081519. PMID 15627748.
  • Litvak V, Dahan N, Ramachandran S, Sabanay H, Lev S (2005). "Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function". Nat. Cell Biol. 7 (3): 225–34. doi:10.1038/ncb1221. PMID 15723057.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Burgis NE, Cunningham RP (2007). "Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase". J. Biol. Chem. 282 (6): 3531–8. doi:10.1074/jbc.M608708200. PMID 17090528.


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