RAB1B

RAB1B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRAB1B, member RAS oncogene family
External IDsMGI: 1923558 HomoloGene: 128838 GeneCards: RAB1B
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.2Start66,268,533 bp[1]
End66,277,492 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

81876

76308

Ensembl

ENSG00000174903

ENSMUSG00000024870

UniProt

Q9H0U4

Q9D1G1

RefSeq (mRNA)

NM_030981

NM_029576

RefSeq (protein)

NP_112243

NP_083852

Location (UCSC)Chr 11: 66.27 – 66.28 MbChr 19: 5.1 – 5.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related protein Rab-1B is a protein that in humans is encoded by the RAB1B gene.[5][6]

Interactions

RAB1B has been shown to interact with GOLGA2.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000174903 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024870 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Chen D, Guo J, Gahl WA (March 1997). "RAB GTPases expressed in human melanoma cells". Biochim Biophys Acta. 1355 (1): 1–6. doi:10.1016/S0167-4889(96)00169-3. PMID 9030196.
  6. ↑ "Entrez Gene: RAB1B RAB1B, member RAS oncogene family".
  7. ↑ Weide, T; Bayer M; Köster M; Siebrasse J P; Peters R; Barnekow A (April 2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b". EMBO Rep. England. 2 (4): 336–41. doi:10.1093/embo-reports/kve065. ISSN 1469-221X. PMC 1083862. PMID 11306556.

Further reading

  • Plutner H, Cox AD, Pind S, et al. (1991). "Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments". J. Cell Biol. 115 (1): 31–43. doi:10.1083/jcb.115.1.31. PMC 2289927. PMID 1918138.
  • Soldati T, Rancaño C, Geissler H, Pfeffer SR (1995). "Rab7 and Rab9 are recruited onto late endosomes by biochemically distinguishable processes". J. Biol. Chem. 270 (43): 25541–8. doi:10.1074/jbc.270.43.25541. PMID 7592724.
  • Wilson AL, Sheridan KM, Erdman RA, Maltese WA (1996). "Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells". Biochem. J. 318 (Pt 3): 1007–14. doi:10.1042/bj3181007. PMC 1217717. PMID 8836150.
  • Overmeyer JH, Wilson AL, Erdman RA, Maltese WA (1998). "The Putative "Switch 2" Domain of the Ras-related GTPase, Rab1B, Plays an Essential Role in the Interaction with Rab Escort Protein". Mol. Biol. Cell. 9 (1): 223–35. doi:10.1091/mbc.9.1.223. PMC 25245. PMID 9437002.
  • Weide T, Koster M, Barnekow A (1999). "Inactive and active mutants of rab1b are not tightly integrated into target membranes". Int. J. Oncol. 15 (4): 727–36. doi:10.3892/ijo.15.4.727. PMID 10493955.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Weide T, Bayer M, Köster M, et al. (2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b". EMBO Rep. 2 (4): 336–41. doi:10.1093/embo-reports/kve065. PMC 1083862. PMID 11306556.
  • Zhao H, Ettala O, Väänänen HK (2002). "Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins". Biochem. Biophys. Res. Commun. 293 (3): 1060–5. doi:10.1016/S0006-291X(02)00326-1. PMID 12051767.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
  • Bayer M, Fischer J, Kremerskothen J, et al. (2006). "Identification and characterization of Iporin as a novel interaction partner for rab1". BMC Cell Biol. 6: 15. doi:10.1186/1471-2121-6-15. PMC 1079803. PMID 15796781.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Monetta P, Slavin I, Romero N, Alvarez C (2007). "Rab1b Interacts with GBF1 and Modulates both ARF1 Dynamics and COPI Association". Mol. Biol. Cell. 18 (7): 2400–10. doi:10.1091/mbc.E06-11-1005. PMC 1924811. PMID 17429068.
  • Machner MP, Isberg RR (2007). "A bifunctional bacterial protein links GDI displacement to Rab1 activation". Science. 318 (5852): 974–7. Bibcode:2007Sci...318..974M. doi:10.1126/science.1149121. PMID 17947549.


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