Oxepin-CoA hydrolase

Oxepin-CoA hydrolase
Identifiers
EC number 3.7.1.16
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Oxepin-CoA hydrolase (EC 3.7.1.16, paaZ (gene)) is an enzyme with systematic name 2-oxepin-2(3H)-ylideneacetyl-CoA hydrolyase.[1][2][3][4] This enzyme catalyses the following chemical reaction

2-oxepin-2(3H)-ylideneacetyl-CoA + H2O 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde

The enzyme is present in bacteria Escherichia coli.

References

  1. Ferrandez, A.; Minambres, B.; Garcia, B.; Olivera, E.R.; Luengo, J.M.; Garcia, J.L.; Diaz, E. (1998). "Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway". J. Biol. Chem. 273 (40): 25974–25986. doi:10.1074/jbc.273.40.25974. PMID 9748275.
  2. Park, S.J.; Lee, S.Y. (2003). "Identification and characterization of a new enoyl coenzyme A hydratase involved in biosynthesis of medium-chain-length polyhydroxyalkanoates in recombinant Escherichia coli". J. Bacteriol. 185 (18): 5391–5397. doi:10.1128/jb.185.18.5391-5397.2003. PMC 193764. PMID 12949091.
  3. Ismail, W.; El-Said Mohamed, M.; Wanner, B.L.; Datsenko, K.A.; Eisenreich, W.; Rohdich, F.; Bacher, A.; Fuchs, G. (2003). "Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli". Eur. J. Biochem. 270 (14): 3047–3054. doi:10.1046/j.1432-1033.2003.03683.x. PMID 12846838.
  4. Teufel, R.; Mascaraque, V.; Ismail, W.; Voss, M.; Perera, J.; Eisenreich, W.; Haehnel, W.; Fuchs, G. (2010). "Bacterial phenylalanine and phenylacetate catabolic pathway revealed". Proc. Natl. Acad. Sci. USA. 107: 14390–14395. doi:10.1073/pnas.1005399107. PMC 2922514. PMID 20660314.
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