Ornithine oxoglutarate

Ornithine oxoglutarate
	Ornithine (top) and ketoglutaric acid (bottom)
Clinical data
ATC code	A05BA06 (WHO) ;
Identifiers
	IUPAC name 2-Oxopentanedioic acid - L-ornithine (1:1);
CAS Number	34414-83-0 ;
PubChem CID	78866;
ChemSpider	71201;
ECHA InfoCard	100.047.261
Chemical and physical data
Formula	C10H18N2O7
Molar mass	278.26 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C(C[C@@H](C(=O)O)N)CN.C(CC(=O)O)C(=O)C(=O)O;
	InChI InChI=1S/C5H12N2O2.C5H6O5/c6-3-1-2-4(7)5(8)9;6-3(5(9)10)1-2-4(7)8/h4H,1-3,6-7H2,(H,8,9);1-2H2,(H,7,8)(H,9,10)/t4-;/m0./s1; Key:SLPUVFBNQHVEEU-WCCKRBBISA-N;
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Ornithine oxoglutarate (OGO) or ornithine α-ketoglutarate (OKG) is a drug used in liver therapy. It is the salt formed from ornithine and alpha-ketoglutaric acid. It is also used to improve nutritional health in elderly patients.^[1]^[2]

References

↑ Blonde-Cynober, F; Aussel, C; Cynober, L (2003). "Use of ornithine α-ketoglutarate in clinical nutrition of elderly patients". Nutrition. 19 (1): 73–5. doi:10.1016/S0899-9007(02)00849-3. PMID 12507647.
↑ Patrice Brocker; Bruno Vellas; Jean-Louis Albarede; Thierry Poynard (July 1994). "A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects". Age and Ageing.

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[1] Blonde-Cynober, F; Aussel, C; Cynober, L (2003). "Use of ornithine α-ketoglutarate in clinical nutrition of elderly patients". Nutrition. 19 (1): 73–5. doi:10.1016/S0899-9007(02)00849-3. PMID 12507647.

[2] Patrice Brocker; Bruno Vellas; Jean-Louis Albarede; Thierry Poynard (July 1994). "A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects". Age and Ageing.

Bile and liver therapy (A05)
Bile therapy	bile acid (Chenodeoxycholic acid Cholic acid Ursodeoxycholic acid) Obeticholic acid Nicotinyl methylamide Piprozolin Hymecromone Cyclobutyrol
Liver therapy	Arginine glutamate Silymarin Citiolone Epomediol Ornithine oxoglutarate Tidiacic arginine Glycyrrhizin

Clinical data

Ornithine (top) and ketoglutaric acid (bottom)
ATC code	A05BA06 (WHO)
Identifiers
IUPAC name 2-Oxopentanedioic acid - L-ornithine (1:1)
CAS Number	34414-83-0^Y
PubChem CID	78866
ChemSpider	71201
ECHA InfoCard	100.047.261
Chemical and physical data
Formula	C₁₀H₁₈N₂O₇
Molar mass	278.26 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C(C[C@@H](C(=O)O)N)CN.C(CC(=O)O)C(=O)C(=O)O
InChI InChI=1S/C5H12N2O2.C5H6O5/c6-3-1-2-4(7)5(8)9;6-3(5(9)10)1-2-4(7)8/h4H,1-3,6-7H2,(H,8,9);1-2H2,(H,7,8)(H,9,10)/t4-;/m0./s1 Key:SLPUVFBNQHVEEU-WCCKRBBISA-N
(verify)