Neoabietadiene synthase

Neoabietadiene synthase
Identifiers
EC number 4.2.3.132
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Neoabietadiene synthase (EC 4.2.3.132, AgAS, PtTPS-LAS) is an enzyme with systematic name (+)-copaly-diphosphate diphosphate-lyase (cyclizing, neoabietadiene-forming).[1][2][3] This enzyme catalyses the following chemical reaction

(+)-copalyl diphosphate neoabietadiene + diphosphate

This enzyme is isolated from Abies grandis (grand fir).

References

  1. ↑ Peters, R.J.; Flory, J.E.; Jetter, R.; Ravn, M.M.; Lee, H.J.; Coates, R.M.; Croteau, R.B. (2000). "A'bietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme". Biochemistry. 39: 15592–15602. doi:10.1021/bi001997l. PMID 11112547.
  2. ↑ Zhou, K.; Gao, Y.; Hoy, J.A.; Mann, F.M.; Honzatko, R.B.; Peters, R.J. (2012). "Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis". J. Biol. Chem. 287 (9): 6840–6850. doi:10.1074/jbc.M111.337592. PMC 3307272. PMID 22219188.
  3. ↑ Ro, D.K.; Bohlmann, J. (2006). "Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1)". Phytochemistry. 67 (15): 1572–1578. doi:10.1016/j.phytochem.2006.01.011. PMID 16497345.
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