NUPL1

NUP58
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JO7, 4JO9, 4JQ5, 5IJN, 5IJO
Identifiers
Aliases	NUP58, PRO2463, NUPL1, NUP45, nucleoporin 58kDa, nucleoporin 58
External IDs	MGI: 1919094 HomoloGene: 40924 GeneCards: NUP58
Gene location (Human)
Chr.	Chromosome 13 (human)[1]
End	25,349,800 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	60,251,507 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• protein binding; • nuclear localization sequence binding; • structural constituent of nuclear pore;
Cellular component	• nuclear membrane; • nuclear envelope; • membrane; • cell nucleus; • nuclear pore; • macromolecular complex;
Biological process	• mRNA transport; • protein heterotetramerization; • protein heterooligomerization; • nucleocytoplasmic transport; • regulation of protein import into nucleus; • protein transport; • viral process; • protein homooligomerization; • mRNA export from nucleus; • protein import into nucleus; • protein heterotrimerization;
	Sources:Amigo / QuickGO
Orthologs
	9818
	71844
	ENSG00000139496
	ENSMUSG00000114797
	Q9BVL2
	Q8R332
	NM_001008564; NM_001008565; NM_014089
	NM_170591; NM_001362439; NM_001362440
	NP_001008564; NP_054808
	NP_733479; NP_001349368; NP_001349369
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleoporin p58/p45 is a protein that in humans is encoded by the NUPL1 gene.^[5]^[6]

This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000139496 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000114797 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
1 2 "Entrez Gene: NUPL1 nucleoporin like 1".

Buss F, Stewart M (1995). "Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62". J. Cell Biol. 128 (3): 251–61. doi:10.1083/jcb.128.3.251. PMC 2120351. PMID 7531196.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Ben-Efraim I, Gerace L (2001). "Gradient of Increasing Affinity of Importin β for Nucleoporins along the Pathway of Nuclear Import". J. Cell Biol. 152 (2): 411–7. doi:10.1083/jcb.152.2.411. PMC 2199621. PMID 11266456.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000139496 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000114797 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid9455477-5] Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.

[entrez-6] 1 2 "Entrez Gene: NUPL1 nucleoporin like 1".

NUPL1

References

Further reading