NDN (gene)

NDN
Identifiers
AliasesNDN, HsT16328, PWCR, necdin, MAGE family member
External IDsMGI: 97290 HomoloGene: 20559 GeneCards: NDN
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q11.2Start23,685,400 bp[1]
End23,687,330 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4692

17984

Ensembl

ENSG00000182636

ENSMUSG00000033585

UniProt

Q99608

P25233

RefSeq (mRNA)

NM_002487

NM_010882

RefSeq (protein)

NP_002478

NP_035012

Location (UCSC)Chr 15: 23.69 – 23.69 MbChr 7: 62.35 – 62.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Necdin is a protein that in humans is encoded by the NDN gene.[5][6]

Function

This intronless gene is located in the Prader-Willi syndrome (PWS) deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mice suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.[6]

Necdin is used to stimulate growth regulation and DNA-dependent transcription regulation.[7]

Interactions

NDN (gene) has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182636 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033585 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ MacDonald HR, Wevrick R (January 1998). "Prader-Willi syndrome and is imprinted". Hum Mol Genet. 6 (11): 1873–8. doi:10.1093/hmg/6.11.1873. PMID 9302265.
  6. 1 2 "Entrez Gene: NDN necdin homolog (mouse)".
  7. ↑ Uniprot
  8. ↑ Taniura H, Taniguchi N, Hara M, Yoshikawa K (January 1998). "Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1". J. Biol. Chem. 273 (2): 720–8. doi:10.1074/jbc.273.2.720. PMID 9422723.
  9. 1 2 Kuwako K, Taniura H, Yoshikawa K (January 2004). "Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor". J. Biol. Chem. 279 (3): 1703–12. doi:10.1074/jbc.M308454200. PMID 14593116.
  10. ↑ Taniura H, Yoshikawa K (2002). "Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix". J. Cell. Biochem. 84 (3): 545–55. doi:10.1002/jcb.10047. PMID 11813259.
  11. ↑ Hu B, Wang S, Zhang Y, Feghali CA, Dingman JR, Wright TM (August 2003). "A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 10008–13. doi:10.1073/pnas.1737765100. PMC 187743. PMID 12913118.
  12. ↑ Bronfman FC, Tcherpakov M, Jovin TM, Fainzilber M (April 2003). "Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome". J. Neurosci. 23 (8): 3209–20. PMID 12716928.
  13. ↑ Tcherpakov M, Bronfman FC, Conticello SG, Vaskovsky A, Levy Z, Niinobe M, Yoshikawa K, Arenas E, Fainzilber M (December 2002). "The p75 neurotrophin receptor interacts with multiple MAGE proteins". J. Biol. Chem. 277 (51): 49101–4. doi:10.1074/jbc.C200533200. PMID 12414813.
  14. ↑ Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K (October 2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. 275 (41): 31674–81. doi:10.1074/jbc.M005103200. PMID 10915798.
  15. ↑ Taniura H, Matsumoto K, Yoshikawa K (June 1999). "Physical and functional interactions of neuronal growth suppressor necdin with p53". J. Biol. Chem. 274 (23): 16242–8. doi:10.1074/jbc.274.23.16242. PMID 10347180.

Further reading

  • Aizawa T, Maruyama K, Kondo H, Yoshikawa K (1992). "Expression of necdin, an embryonal carcinoma-derived nuclear protein, in developing mouse brain". Brain Res. Dev. Brain Res. 68 (2): 265–74. doi:10.1016/0165-3806(92)90069-9. PMID 1394972.
  • Jay P, Rougeulle C, Massacrier A, Moncla A, Mattei MG, Malzac P, Roëckel N, Taviaux S, Lefranc JL, Cau P, Berta P, Lalande M, Muscatelli F (1997). "The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region". Nat. Genet. 17 (3): 357–61. doi:10.1038/ng1197-357. PMID 9354807.
  • Taniura H, Taniguchi N, Hara M, Yoshikawa K (1998). "Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1". J. Biol. Chem. 273 (2): 720–8. doi:10.1074/jbc.273.2.720. PMID 9422723.
  • Nakada Y, Taniura H, Uetsuki T, Inazawa J, Yoshikawa K (1998). "The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region". Gene. 213 (1–2): 65–72. doi:10.1016/S0378-1119(98)00206-6. PMID 9630521.
  • Taniura H, Matsumoto K, Yoshikawa K (1999). "Physical and functional interactions of neuronal growth suppressor necdin with p53". J. Biol. Chem. 274 (23): 16242–8. doi:10.1074/jbc.274.23.16242. PMID 10347180.
  • Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K (2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. 275 (41): 31674–81. doi:10.1074/jbc.M005103200. PMID 10915798.
  • Niinobe M, Koyama K, Yoshikawa K (2000). "Cellular and subcellular localization of necdin in fetal and adult mouse brain". Dev. Neurosci. 22 (4): 310–9. doi:10.1159/000017455. PMID 10965153.
  • Taniura H, Yoshikawa K (2002). "Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix". J. Cell. Biochem. 84 (3): 545–55. doi:10.1002/jcb.10047. PMID 11813259.
  • Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
  • Kobayashi M, Taniura H, Yoshikawa K (2003). "Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells". J. Biol. Chem. 277 (44): 42128–35. doi:10.1074/jbc.M205024200. PMID 12198120.
  • Tcherpakov M, Bronfman FC, Conticello SG, Vaskovsky A, Levy Z, Niinobe M, Yoshikawa K, Arenas E, Fainzilber M (2003). "The p75 neurotrophin receptor interacts with multiple MAGE proteins". J. Biol. Chem. 277 (51): 49101–4. doi:10.1074/jbc.C200533200. PMID 12414813.
  • Bronfman FC, Tcherpakov M, Jovin TM, Fainzilber M (2003). "Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome". J. Neurosci. 23 (8): 3209–20. PMID 12716928.
  • Hu B, Wang S, Zhang Y, Feghali CA, Dingman JR, Wright TM (2003). "A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 10008–13. doi:10.1073/pnas.1737765100. PMC 187743. PMID 12913118.
  • Kuwako K, Taniura H, Yoshikawa K (2004). "Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor". J. Biol. Chem. 279 (3): 1703–12. doi:10.1074/jbc.M308454200. PMID 14593116.
  • Lau JC, Hanel ML, Wevrick R (2004). "Tissue-specific and imprinted epigenetic modifications of the human NDN gene". Nucleic Acids Res. 32 (11): 3376–82. doi:10.1093/nar/gkh671. PMC 443546. PMID 15247330.
  • Moon HE, Ahn MY, Park JA, Min KJ, Kwon YW, Kim KW (2005). "Negative regulation of hypoxia inducible factor-1alpha by necdin". FEBS Lett. 579 (17): 3797–801. doi:10.1016/j.febslet.2005.05.072. PMID 15978586.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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