Nucleobindin 2

NUCB2
Identifiers
AliasesNUCB2, HEL-S-109, NEFA, nucleobindin 2
External IDsMGI: 1858179 HomoloGene: 3676 GeneCards: NUCB2
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.1Start17,208,153 bp[1]
End17,349,974 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4925

53322

Ensembl

ENSG00000070081

ENSMUSG00000030659

UniProt

P80303

P81117

RefSeq (mRNA)

NM_001130479
NM_016773
NM_001360375

RefSeq (protein)

NP_001123951
NP_001347304

Location (UCSC)Chr 11: 17.21 – 17.35 MbChr 7: 116.5 – 116.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleobindin-2 is a protein that in humans is encoded by the NUCB2 gene.[5][6]

Nucleobindin-2 is a calcium-binding EF-hand protein.[supplied by OMIM][6]

Interactions

NUCB2 has been shown to interact with NDN.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000070081 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030659 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Barnikol-Watanabe S, Gross NA, Gotz H, Henkel T, Karabinos A, Kratzin H, Barnikol HU, Hilschmann N (February 1995). "Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein". Biol Chem Hoppe-Seyler. 375 (8): 497–512. doi:10.1515/bchm3.1994.375.8.497. PMID 7811391.
  6. 1 2 "Entrez Gene: NUCB2 nucleobindin 2".
  7. ↑ Taniguchi, N; Taniura H; Niinobe M; Takayama C; Tominaga-Yoshino K; Ogura A; Yoshikawa K (October 2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. UNITED STATES. 275 (41): 31674–81. doi:10.1074/jbc.M005103200. ISSN 0021-9258. PMID 10915798.

Further reading

  • DeAngelis MM, Doucet JP, Drury S, et al. (1998). "Assembly of a high-resolution map of the Acadian Usher syndrome region and localization of the nuclear EF-hand acidic gene". Biochim. Biophys. Acta. 1407 (1): 84–91. doi:10.1016/s0925-4439(98)00025-8. PMID 9639681.
  • Kroll KA, Otte S, Hirschfeld G, et al. (1999). "Heterologous overexpression of human NEFA and studies on the two EF-hand calcium-binding sites". Biochem. Biophys. Res. Commun. 260 (1): 1–8. doi:10.1006/bbrc.1999.0867. PMID 10381334.
  • Taniguchi N, Taniura H, Niinobe M, et al. (2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. 275 (41): 31674–81. doi:10.1074/jbc.M005103200. PMID 10915798.
  • Nesselhut J, Jurgan U, Onken E, et al. (2002). "Golgi retention of human protein NEFA is mediated by its N-terminal Leu/Ile-rich region". FEBS Lett. 509 (3): 469–75. doi:10.1016/S0014-5793(01)03187-8. PMID 11749975.
  • Linē A, Stengrēvics A, Slucka Z, et al. (2002). "Serological identification and expression analysis of gastric cancer-associated genes". Br. J. Cancer. 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMC 2375403. PMID 12087473.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Islam A, Adamik B, Hawari FI, et al. (2006). "Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex". J. Biol. Chem. 281 (10): 6860–73. doi:10.1074/jbc.M509397200. PMID 16407280.


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