NADH:ubiquinone reductase (Na+-transporting)

Na(+)-translocating NADH-quinone reductase
Identifiers
Symbol NQR
Pfam PF03116
TCDB 3.D.5
OPM superfamily 372
OPM protein 4pbv
NADH:ubiquinone reductase (Na+-transporting)
Identifiers
EC number 1.6.5.8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

NADH:ubiquinone reductase (Na+-transporting) (EC 1.6.5.8 is an enzyme with systematic name NADH:ubiquinone oxidoreductase (Na+-translocating). In bacteria, three different types of respiratory NADH:quinone oxidoreductases (NQr) have been described: the electrogenic complex I, also called NDH I in bacteria, the non-electrogenic NADH:quinone oxidoreductases (NDH II), and the Na+-translocating NADH:quinone oxidoreductases Na+-NQr. The common function of these transmembrane enzymes in respiration is to oxidize NADH using ubiquinone (Q) as electron acceptor. The net reaction thus yields ubiquinol (QH2), the reducing substrate of enzyme complexes further along the respiratory chain, and NAD+, which is used as oxidizing agent in numerous cellular processes.[1]

NADH + H+ + ubiquinone + n Na+in → NAD+ + ubiquinol + n Na+out

The enzyme is iron-sulfur flavoprotein.

References

  1. ↑ Fritz, Günter; Steuber, Julia (2016). "Chapter 11. Sodium as Coupling Cation in Respiratory Energy Conversion". In Astrid, Sigel; Helmut, Sigel; Roland K.O., Sigel. The Alkali Metal Ions: Their Role in Life. Metal Ions in Life Sciences. 16. Springer. pp. 349–390. doi:10.1007/978-4-319-21756-7_11.
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