N1-acetylpolyamine oxidase

N1-acetylpolyamine oxidase
Identifiers
EC number 1.5.3.13
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

N1-acetylpolyamine oxidase (EC 1.5.3.13, hPAO-1, mPAO, hPAO) is an enzyme with systematic name N1-acetylpolyamine:oxygen oxidoreductase (3-acetamidopropanal-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction

(1) N1-acetylspermidine + O2 + H2O putrescine + 3-acetamidopropanal + H2O2
(2) N1-acetylspermine + O2 + H2O spermidine + 3-acetamidopropanal + H2O2

This enzyme also catalyses the reaction:

N1,N12-diacetylspermine + O2 + H2O N1-acetylspermidine + 3-acetamamidopropanal + H2O2.

References

  1. ↑ Vujcic S, Liang P, Diegelman P, Kramer DL, Porter CW (February 2003). "Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion". The Biochemical Journal. 370 (Pt 1): 19–28. doi:10.1042/BJ20021779. PMC 1223169. PMID 12477380.
  2. ↑ Järvinen A, Grigorenko N, Khomutov AR, Hyvönen MT, Uimari A, Vepsäläinen J, Sinervirta R, Keinänen TA, Vujcic S, Alhonen L, Porter CW, Jänne J (February 2005). "Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines". The Journal of Biological Chemistry. 280 (8): 6595–601. doi:10.1074/jbc.M412788200. PMID 15611107.
  3. ↑ Wang Y, Hacker A, Murray-Stewart T, Frydman B, Valasinas A, Fraser AV, Woster PM, Casero RA (July 2005). "Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity". Cancer Chemotherapy and Pharmacology. 56 (1): 83–90. doi:10.1007/s00280-004-0936-5. PMID 15791459.
  4. ↑ Wu T, Yankovskaya V, McIntire WS (June 2003). "Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase". The Journal of Biological Chemistry. 278 (23): 20514–25. doi:10.1074/jbc.M302149200. PMID 12660232.
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