Myeloblastin

Myeloblastin
Identifiers
EC number 3.4.21.76
CAS number 128028-50-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Myeloblastin (EC 3.4.21.76, leukocyte proteinase 3, leukocyte proteinase 4, Wegener's granulomatosis autoantigen, proteinase PR-3, proteinase-3, PMNL proteinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- > -Val-

This enzyme is present in polymorphonuclear leukocyte granules. Downregulation of myeloblastin in promyelocytic leukemia cells was shown to induce their growth arrest and differentiation.[4]

See also

References

  1. ↑ Martin KR, Witko-Sarsat V (September 2017). "Proteinase 3: the odd one out that became an autoantigen". Journal of Leukocyte Biology. 102 (3): 689–698. doi:10.1189/jlb.3MR0217-069R. PMID 28546501.
  2. ↑ Brubaker MJ, Groutas WC, Hoidal JR, Rao NV (November 1992). "Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters". Biochemical and Biophysical Research Communications. 188 (3): 1318–24. doi:10.1016/0006-291x(92)91375-z. PMID 1445363.
  3. ↑ Kam CM, Kerrigan JE, Dolman KM, Goldschmeding R, Von dem Borne AE, Powers JC (February 1992). "Substrate and inhibitor studies on proteinase 3". FEBS Letters. 297 (1–2): 119–23. doi:10.1016/0014-5793(92)80340-m. PMID 1551417.
  4. ↑ Bories D, Raynal MC, Solomon DH, Darzynkiewicz Z, Cayre YE (December 1989). "Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells". Cell. 59 (6): 959–68. PMID 2598267.
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