Mycothiol synthase
| Mycothiol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.189 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Mycothiol synthase (EC 2.3.1.189, MshD) is an enzyme with systematic name acetyl-CoA:desacetylmycothiol O-acetyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- desacetylmycothiol + acetyl-CoA CoA + mycothiol
This enzyme catalyses the last step in the biosynthesis of mycothiol
References
- ↑ Spies, H.S.; Steenkamp, D.J. (1994). "Thiols of intracellular pathogens. Identification of ovothiol A in Leishmania donovani and structural analysis of a novel thiol from Mycobacterium bovis". Eur. J. Biochem. 224: 203–213. doi:10.1111/j.1432-1033.1994.tb20013.x. PMID 8076641.
- ↑ Koledin, T.; Newton, G.L.; Fahey, R.C. (2002). "Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes". Arch. Microbiol. 178: 331–337. doi:10.1007/s00203-002-0462-y. PMID 12375100.
- ↑ Vetting, M.W.; Roderick, S.L.; Yu, M.; Blanchard, J.S. (2003). "Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases". Protein Sci. 12: 1954–1959. doi:10.1110/ps.03153703. PMC 2323992. PMID 12930994.
External links
- Mycothiol+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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