Methylthioribulose 1-phosphate dehydratase

methylthioribulose 1-phosphate dehydratase
X-ray structure of human methylthioribulose 1-phosphate dehydratase (APIP). PDB entry 4m6r[1]
Identifiers
EC number 4.2.1.109
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a methylthioribulose 1-phosphate dehydratase (EC 4.2.1.109) is an enzyme that catalyzes the chemical reaction

S-methyl-5-thio-D-ribulose 1-phosphate 5-(methylthio)-2,3-dioxopentyl phosphate + H2O

Hence, this enzyme has one substrate, S-methyl-5-thio-D-ribulose 1-phosphate, and two products, 5-(methylthio)-2,3-dioxopentyl phosphate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is S-methyl-5-thio-D-ribulose-1-phosphate 4-hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]. Other names in common use include 1-PMT-ribulose dehydratase, and S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase. This enzyme participates in methionine metabolism.

References

  1. ↑ Kang, W; Hong, S. H.; Lee, H. M.; Kim, N. Y.; Lim, Y. C.; Le Le, T. M.; Lim, B; Kim, H. C.; Kim, T. Y.; Ashida, H; Yokota, A; Hah, S. S.; Chun, K. H.; Jung, Y. K.; Yang, J. K. (2014). "Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme". Proceedings of the National Academy of Sciences. 111 (1): E54–61. doi:10.1073/pnas.1308768111. PMC 3890807. PMID 24367089.
  • Furfine ES, Abeles RH (1988). "Intermediates in the conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae". J. Biol. Chem. 263 (20): 9598&ndash, 606. PMID 2838472.
  • Wray JW, Abeles RH (1995). "The methionine salvage pathway in Klebsiella pneumoniae and rat liver. Identification and characterization of two novel dioxygenases". J. Biol. Chem. 270 (7): 3147&ndash, 53. doi:10.1074/jbc.270.7.3147. PMID 7852397.
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