Matthias Hentze

Matthias Hentze
Born (1960-01-25) January 25, 1960
Wiedenbrück, Germany[1]
Residence Heidelberg, Germany
Nationality German
Citizenship German
Alma mater Westfälische Wilhelms-Universität Münster
Scientific career
Fields Molecular Biology, RNA-binding proteins
Institutions
Thesis "Influence of amino acid analogs on maturation, transport and stability of cathepsin D in human skin fibroblasts" (1984)
Website www.embl.de

Matthias Werner Hentze (born 25 January 1960 in Wiedenbrück, West Germany) is a German scientist. He is the Director of the European Molecular Biology Laboratory (EMBL)[4] and Professor of Molecular Medicine at Heidelberg University.[5]

Biography

Matthias Hentze studied medicine in the UK at the medical schools at the University of Southampton, University of Oxford, University of Glasgow and University of Cambridge, and in Germany at the Westfälische Wilhelms-Universität, Münster from which he qualified in 1984.[1] In the same year, he received his M.D. degree; he wrote a dissertation on the role of glycosylation in lysosomal enzyme stability with Kurt von Figura as his advisor.[1][6][7]

After a short phase of clinical work Hentze became a postdoctoral fellow at the National Institutes of Health in 1985.[8] In 1989, he joined the European Molecular Biology Laboratory in Heidelberg as an independent group leader.[9] At the age of 30, he obtained the Habilitation from the Ruprecht-Karls University in Heidelberg.[1] He served as Dean of the EMBL International Ph.D. Programme from 1996 until 2005, when he became Associate Director of the EMBL and Professor for Molecular Medicine at the University of Heidelberg.[1] Together with Prof. Andreas Kulozik of the Medical Faculty of Heidelberg University, Hentze co-founded the Molecular Medicine Partnership Unit (MMPU) in the early 2000s and serves as its Co-Director.[10] Technology invented at EMBL was licensed to Anadys Pharmaceuticals when that company pivoted and was renamed from Scriptgen Pharmaceuticals around 2000, and Hentze and other EMBL staff became members of its scientific advisory board.[11]

In 2013, Hentze became the Director of EMBL, advising and supporting EMBL's Director General, Iain Mattaj.[4]

Research

In 1987, Hentze and his colleagues discovered iron-responsive elements that regulate the translation of mammalian mRNA into proteins.[8][12] He has also studied the relationship between iron metabolism and disease and diseases of RNA metabolism, especially those relating to the Nonsense-mediated decay pathway and RNA 3′-end formation. Since around 2010 Hentze has studied RNA-binding enzymes that connect cellular metabolism and gene expression.[13]

Hentze has hypothesized ways that gene expression and metabolism are coordinated by interactions among RNA, enzymes and metabolites, and calls this set of interactions "REM networks".[14] Work following the hypothesis has identified hundreds of formerly unknown RNA-binding proteins in living organisms from human to yeast.[15][16]

Honors and awards

Editorial Boards

  • Trends in Biochemical Sciences [TiBS] (since 1996) [31]
  • RNA (since 1997) [32]
  • Molecular Cell (since 2004) [33]
  • BioMed Central Molecular Biology (since 2003) [34]
  • J. Molecular Medicine (since 2004) [35]
  • Senior Editor, EMBO Molecular Medicine (since 2008) [36]
  • International Advisory Board, Wiley Interdisciplinary Reviews RNA (since 2009) [37]

References

  1. 1 2 3 4 5 6 Leopoldina CV. Retrieved 2015-06-12.
  2. ↑ National Institutes of Health Retrieved 2015-08-06.
  3. ↑ EMBL Homepage Archived 2008-11-13 at the Wayback Machine. Retrieved 2015-08-06.
  4. 1 2 EMBL Leadership. Retrieved 2015-06-12.
  5. ↑ Faculty at Heidelberg University Hospital. Retrieved 2015-06-12.
  6. ↑ German National Library. Retrieved 2015-07-20.
  7. ↑ Hentze, M.; Hasilik, A.; Figura, Kurt v. (1984). "Enhanced degradation of Cathepsin D synthesized in the presence of the threonine analog beta-hydroxynorvaline". Arch. Biochem. Biophys. 230 (1): 375–82. doi:10.1016/0003-9861(84)90120-6. PMID 6424571. Retrieved 2015-08-06.
  8. 1 2 Hentze, M (December 2012). "An interview with Matthias Hentze". Trends in Biochemical Sciences. 37 (12): 507–8. doi:10.1016/j.tibs.2012.09.004. PMID 23047134.
  9. ↑ AARS 2015 - Keynote Speakers. Retrieved 2015-06-12.
  10. ↑ Smaglik, P (15 May 2003). "Language lessons: Heidelberg". Nature. 423 (6937): 364–5. doi:10.1038/nj6937-364a. PMID 12748657.
  11. ↑ "Amendment No. 7 To Form S-1". Anadys via SEC Edgar. March 24, 2004.
  12. ↑ Addess, KJ; Basilion, JP; Klausner, RD; Rouault, TA; Pardi, A (21 November 1997). "Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins". Journal of Molecular Biology. 274 (1): 72–83. doi:10.1006/jmbi.1997.1377. PMID 9398517.
  13. ↑ Life Scientist: Enzymes with alter egos. Feb. 2014. Retrieved 2015-06-12.
  14. ↑ Hentze, Matthias; Thomas, Preiss (2010). "The REM phase of gene regulation". Trends in Biochemical Sciences. 35 (8): 423–6. doi:10.1016/j.tibs.2010.05.009. PMID 20554447.
  15. ↑ Castello, Alfredo; Fischer, Bernd; Eichelbaum, Katrin; et al. (2012). "Insights into RNA biology from an atlas of mammalian mRNA-binding proteins". Cell. 149 (6): 1393–406. doi:10.1016/j.cell.2012.04.031. PMID 22658674.
  16. ↑ Kwon, S Chul; et al. (2013). "The RNA-binding protein repertoire of embryonic stem cells". Nature Structural & Molecular Biology. 20 (9): 1122–30. doi:10.1038/nsmb.2638. PMID 23912277.
  17. ↑ EMBO Membership Directory. Retrieved 2015-07-20.
  18. ↑ DFG German Research Foundation. Retrieved 2015-06-12.
  19. ↑ Gottfried Wilhelm Leibniz Programme 2000. Retrieved 2015-07-20.
  20. ↑ EURASC Membership Directory. Retrieved 2015-07-20.
  21. ↑ Leopoldina. Nationale Akadamie der Wissenschaften. Retrieved 2015-08-06.
  22. ↑ Lautenschläger-Research Prize 2007 for Prof. Dr. Matthias Hentze and Prof. Dr. Andreas Kulozik. Retrieved 2015-06-12.
  23. ↑ Biotechnology and Life Sciences in Baden-Württemberg. Retrieved 2015-07-20. Archived 2015-04-05 at the Wayback Machine.
  24. ↑ RNA Society. Directors. Retrieved 2016-04-04
  25. ↑ 66th Mosbacher Kolloquium 2015. Retrieved 2015-06-12. Archived 2015-06-02 at Archive.is
  26. ↑ Biospektrum.de. Retrieved 2015-07-20.
  27. ↑ "Profile: Hentze Matthias". Academy of Europe. Retrieved 7 September 2017.
  28. ↑ Australian Academy of Science/News and events. Retrieved 2018-07-30.
  29. ↑ ANU. Research. Highlights. Retrieved 2018-07-30.
  30. ↑ American Academy of Arts and Sciences. Newly Elected Fellows. Retrieved 2018-05-15.
  31. ↑ TiBS Editorial Board. Retrieved 2015-07-20.
  32. ↑ RNA Editorial Board. Date retr. 07-20-2015
  33. ↑ Cell Editorial Board. Retrieved 2015-07-20.
  34. ↑ BMC Molecular Biology Editorial Board. Retrieved 2015-07-20.
  35. ↑ Journal of Molecular Medicine Editorial Board. Retrieved 2015-07-20.
  36. ↑ EMBO Press - Editors & Advisory Editorial Board. Retrieved 2015-07-20.
  37. ↑ "Issue information". Wiley Interdisciplinary Reviews: RNA. 6 (1). 2014. doi:10.1002/wrna.1275.
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