Malyl-CoA lyase
| malyl-CoA lyase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.1.3.24 | ||||||||
| CAS number | 37290-67-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a malyl-CoA lyase (EC 4.1.3.24) is an enzyme that catalyzes the chemical reaction
- (3S)-3-carboxy-3-hydroxypropanoyl-CoA acetyl-CoA + glyoxylate
Hence, this enzyme has one substrate, (3S)-3-carboxy-3-hydroxypropanoyl-CoA, and two products, acetyl-CoA and glyoxylate.
This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming). Other names in common use include malyl-coenzyme A lyase, and (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase. This enzyme participates in glyoxylate and dicarboxylate metabolism.
References
- Tuboi S; Kikuchi G (1965). "Enzymic cleavage of malyl-Coenzyme A into acetyl-Coenzyme A and glyoxylic acid". Biochim. Biophys. Acta. 96: 148&ndash, 153. doi:10.1016/0005-2787(65)90618-0.
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