Malonate decarboxylase holo-(acyl-carrier protein) synthase

Malonate decarboxylase holo-(acyl-carrier protein) synthase
Identifiers
EC number 2.7.7.66
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Malonate decarboxylase holo-(acyl-carrier protein) synthase (EC 2.7.7.66, holo ACP synthase, 2'-(5-triphosphoribosyl)-3'-dephospho-CoA:apo ACP 2'-(5-triphosphoribosyl)-3'-dephospho-CoA transferase, MdcG, 2'-(5-triphosphoribosyl)-3'-dephospho-CoA:apo-malonate-decarboxylase adenylyltransferase, holo-malonate-decarboxylase synthase) is an enzyme with systematic name 2'-(5-triphosphoribosyl)-3'-dephospho-CoA:apo-malonate-decarboxylase 2'-(5-phosphoribosyl)-3'-dephospho-CoA-transferase.[1][2] This enzyme catalyses the following chemical reaction

2'-(5-triphosphoribosyl)-3'-dephospho-CoA + malonate decarboxylase apo-[acyl-carrier protein] malonate decarboxylase holo-[acyl-carrier protein] + diphosphate

The delta subunit of malonate decarboxylase serves as an acyl-carrier protein (ACP) .

References

  1. ↑ Hoenke S, Wild MR, Dimroth P (October 2000). "Biosynthesis of triphosphoribosyl-dephospho-coenzyme A, the precursor of the prosthetic group of malonate decarboxylase". Biochemistry. 39 (43): 13223–32. doi:10.1021/bi0011532. PMID 11052675.
  2. ↑ Hoenke S, Schmid M, Dimroth P (October 2000). "Identification of the active site of phosphoribosyl-dephospho-coenzyme A transferase and relationship of the enzyme to an ancient class of nucleotidyltransferases". Biochemistry. 39 (43): 13233–40. doi:10.1021/bi001154u. PMID 11052676.
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