MOCOS

MOCOS
Identifiers
AliasesMOCOS, HMCS, MCS, MOS, molybdenum cofactor sulfurase
External IDsMGI: 1915841 HomoloGene: 9931 GeneCards: MOCOS
Gene location (Human)
Chr.Chromosome 18 (human)[1]
Band18q12.2Start36,187,519 bp[1]
End36,272,157 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55034

68591

Ensembl

ENSG00000075643

ENSMUSG00000039616

UniProt

Q96EN8

Q14CH1

RefSeq (mRNA)

NM_017947

NM_026779

RefSeq (protein)

NP_060417

NP_081055

Location (UCSC)Chr 18: 36.19 – 36.27 MbChr 18: 24.65 – 24.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Molybdenum cofactor sulfurase is an enzyme that in humans is encoded by the MOCOS gene.[5][6]

MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH) and aldehyde oxidase (AOX1), which is required for their enzymatic activities.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000075643 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039616 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Ichida K, Matsumura T, Sakuma R, Hosoya T, Nishino T (Apr 2001). "Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II". Biochem Biophys Res Commun. 282 (5): 1194–200. doi:10.1006/bbrc.2001.4719. PMID 11302742.
  6. ↑ "Entrez Gene: MOCOS molybdenum cofactor sulfurase".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yamamoto T, Moriwaki Y, Takahashi S (2003). "Identification of a new point mutation in the human molybdenum cofactor sulferase gene that is responsible for xanthinuria type II". Metab. Clin. Exp. 52 (11): 1501–4. doi:10.1016/s0026-0495(03)00272-5. PMID 14624414.
  • Beausoleil SA, Jedrychowski M, Schwartz D (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Villén J, Gerber SA (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
  • Peretz H, Naamati MS, Levartovsky D (2007). "Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS) associated with type II classical xanthinuria". Mol. Genet. Metab. 91 (1): 23–9. doi:10.1016/j.ymgme.2007.02.005. PMID 17368066.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.