MCF2L

MCF2L
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMCF2L, ARHGEF14, DBS, OST, MCF.2 cell line derived transforming sequence like
External IDsMGI: 103263 HomoloGene: 11804 GeneCards: MCF2L
Gene location (Human)
Chr.Chromosome 13 (human)[1]
Band13q34Start112,894,378 bp[1]
End113,099,739 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23263

17207

Ensembl

ENSG00000126217

ENSMUSG00000031442

UniProt

O15068

Q64096

RefSeq (mRNA)

NM_001112732
NM_024979
NM_001320815
NM_001320816
NM_001320817

NM_001159485
NM_001159486
NM_178076

RefSeq (protein)

NP_001106203
NP_001307744
NP_001307745
NP_001307746
NP_079255

n/a

Location (UCSC)Chr 13: 112.89 – 113.1 MbChr 8: 12.87 – 13.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide exchange factor DBS is a protein that in humans is encoded by the MCF2L gene.[5][6]

Model organisms

Model organisms have been used in the study of MCF2L function. A conditional knockout mouse line called Mcf2ltm1a(EUCOMM)Hmgu was generated at the Wellcome Trust Sanger Institute.[7] Male and female animals underwent a standardized phenotypic screen[8] to determine the effects of deletion.[9][10][11][12] Additional screens performed: - In-depth immunological phenotyping[13]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000126217 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031442 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  6. ↑ "Entrez Gene: MCF2L MCF.2 cell line derived transforming sequence-like".
  7. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  8. 1 2 "International Mouse Phenotyping Consortium".
  9. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  10. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  11. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  12. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  13. 1 2 "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

  • Horii Y, Beeler JF, Sakaguchi K, Tachibana M, Miki T (Oct 1994). "A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways". The EMBO Journal. 13 (20): 4776–86. PMC 395416. PMID 7957046.
  • Rossman KL, Worthylake DK, Snyder JT, Siderovski DP, Campbell SL, Sondek J (Mar 2002). "A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange". The EMBO Journal. 21 (6): 1315–26. doi:10.1093/emboj/21.6.1315. PMC 125919. PMID 11889037.
  • Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J (Jun 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nature Structural Biology. 9 (6): 468–75. doi:10.1038/nsb796. PMID 12006984.
  • Yamauchi J, Hirasawa A, Miyamoto Y, Kokubu H, Nishii H, Okamoto M, Sugawara Y, Tsujimoto G, Itoh H (Aug 2002). "Role of Dbl's big sister in the anti-mitogenic pathway from alpha1B-adrenergic receptor to c-Jun N-terminal kinase". Biochemical and Biophysical Research Communications. 296 (1): 85–92. doi:10.1016/S0006-291X(02)00839-2. PMID 12147231.
  • Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ (Dec 2002). "RhoG signals in parallel with Rac1 and Cdc42". The Journal of Biological Chemistry. 277 (49): 47810–7. doi:10.1074/jbc.M203816200. PMID 12376551.
  • Cheng L, Mahon GM, Kostenko EV, Whitehead IP (Mar 2004). "Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1". The Journal of Biological Chemistry. 279 (13): 12786–93. doi:10.1074/jbc.M313099200. PMID 14701795.
  • Ueda S, Kataoka T, Satoh T (Aug 2004). "Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites". Cellular Signalling. 16 (8): 899–906. doi:10.1016/j.cellsig.2004.01.007. PMID 15157669.
  • Kostenko EV, Mahon GM, Cheng L, Whitehead IP (Jan 2005). "The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs". The Journal of Biological Chemistry. 280 (4): 2807–17. doi:10.1074/jbc.M411139200. PMID 15531584.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Ieguchi K, Ueda S, Kataoka T, Satoh T (Aug 2007). "Role of the guanine nucleotide exchange factor Ost in negative regulation of receptor endocytosis by the small GTPase Rac1". The Journal of Biological Chemistry. 282 (32): 23296–305. doi:10.1074/jbc.M700950200. PMID 17562712.


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