Labdatriene synthase

Labdatriene synthase
Identifiers
EC number 4.2.3.99
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Labdatriene synthase (EC 4.2.3.99, OsKSL10 (gene)) is an enzyme with systematic name 9alpha-copalyl-diphosphate diphosphate-lyase ((12E)-9alpha-labda-8(17),12,14-triene-forming).[1] This enzyme catalyses the following chemical reaction

9alpha-copalyl diphosphate (12E)-9alpha-labda-8(17),12,14-triene + diphosphate

The enzyme from rice (Oryza sativa) also produces ent-sandaracopimara-8(14),15-diene from ent-copalyl diphosphate.

References

  1. Morrone, D.; Hillwig, M.L.; Mead, M.E.; Lowry, L.; Fulton, D.B.; Peters, R.J. (2011). "Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals". Biochem. J. 435: 589–595. doi:10.1042/bj20101429. PMC 3723722. PMID 21323642.
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