LANCL1

LANCL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E6U, 3E73
Identifiers
Aliases	LANCL1, GPR69A, p40, LanC like 1
External IDs	MGI: 1336997 HomoloGene: 4417 GeneCards: LANCL1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q34 Start 210,431,249 bp[1] End 210,477,652 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C3 Start 67,000,517 bp[2] End 67,038,872 bp[2]
Gene ontology Molecular function • SH3 domain binding • low-density lipoprotein particle receptor binding • zinc ion binding • protein binding • G-protein coupled receptor activity • metal ion binding • glutathione binding • catalytic activity Cellular component • cytoplasm • integral component of plasma membrane • membrane • plasma membrane Biological process • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10314	14768
Ensembl	ENSG00000115365	ENSMUSG00000026000
UniProt	O43813	O89112
RefSeq (mRNA)	NM_001136574 NM_001136575 NM_006055	NM_001190984 NM_001190985 NM_021295
RefSeq (protein)	NP_001130046 NP_001130047 NP_006046	NP_001177913 NP_001177914 NP_067270
Location (UCSC)	Chr 2: 210.43 – 210.48 Mb	Chr 1: 67 – 67.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

LanC like 1 is a protein that in humans is encoded by the LANCL1 gene. ^[5]

Function

This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.