Kentucky Route 181

Todd County

KY 181 starts at a crossroads junction with US Route 79 and Kentucky Route 2128 located near the Tennessee state border in the town of Guthrie, in southern Todd County. This is about 0.28 miles (0.45 km) north of the state line separating Todd County from Montgomery County, Tennessee. KY 181 has junctions with KY 294 and then a crossroad intersection with US Route 41. KY 181 goes north to intersect with KY 848, and then KY 104 before making it into the Todd County seat of Elkton. It intersects US Route 68 Business in downtown Elkton, while it crosses the Jefferson Davis Highway, the real US Route 68, which runs concurrently with Kentucky Route 80 just north of the city limits. Kentucky Route 106 has a junction with KY 181 just after the US 68 junction. Junctions with KY 171 and KY 507 will follow after KY 181 leaves the Elkton area. ^[2]

At Clifty, Kentucky Route 107 runs concurrent with KY 181 for 2.01 miles (3.23 km) through that community, with a junction with KY 890 located within that concurrency. It intersects KY 1785 before entering Muhlenberg County. ^{[3] [4]}

Muhlenberg County

After making its entrance into Muhlenberg County, KY 181 has a junction with Kentucky Route 973, which provides access to the Lake Malone State Park. Another junction with KY 890 follows, and then KY 1163 (Old Russellville Pike) before reaching the city of Greenville. In downtown Greenville, it would meet US Route 62 (US 62) and KY 176 in the town square. KY 181 crosses the four-lane KY 189 by-pass before meeting the Exit 53 interchange with the Wendell H. Ford Western Kentucky Parkway. It then intersects KY 70 at Midland before reaching its northern terminus at the KY 81 junction in the community of Bremen just short of the McLean County line. ^{[3] [4]}