Juglone 3-monooxygenase

juglone 3-monooxygenase
Identifiers
EC number 1.14.99.27
CAS number 98865-54-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, juglone 3-monooxygenase (EC 1.14.99.27) is an enzyme that catalyzes the chemical reaction

5-hydroxy-1,4-naphthoquinone + AH2 + O2 3,5-dihydroxy-1,4-naphthoquinone + A + H2O

The 3 substrates of this enzyme are 5-hydroxy-1,4-naphthoquinone, AH2, and O2, whereas its 3 products are 3,5-dihydroxy-1,4-naphthoquinone, A, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O miscellaneous. The systematic name of this enzyme class is 5-hydroxy-1,4-naphthoquinone,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating). Other names in common use include juglone hydroxylase, naphthoquinone hydroxylase, and naphthoquinone-hydroxylase.

References

    • Rettenmaier H, Lingens F (1985). "Purification and some properties of two isofunctional juglone hydroxylases from Pseudomonas putida J1". Biol. Chem. Hoppe-Seyler. 366 (7): 637&ndash, 46. doi:10.1515/bchm3.1985.366.2.637. PMID 4041238.


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