Isopropyl myristate

Isopropyl myristate[1]
Names
IUPAC name
Propan-2-yl tetradecanoate
Other names
Tetradecanoic acid, 1-methylethyl ester
Myristic acid isopropyl ester
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.003.412
EC Number 203-751-4
KEGG
MeSH C008205
RTECS number XB8600000
Properties
C17H34O2
Molar mass 270.46 g·mol−1
Density 0.85 g/cm³
Boiling point 167 °C (333 °F; 440 K) at 9 mmHg
Hazards
R-phrases (outdated) R38
S-phrases (outdated) S24/25
NFPA 704
Flammability code 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g., canola oilHealth code 0: Exposure under fire conditions would offer no hazard beyond that of ordinary combustible material. E.g., sodium chlorideReactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogenSpecial hazards (white): no codeNFPA 704 four-colored diamond
1
0
0
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Isopropyl myristate is the ester of isopropyl alcohol and myristic acid.

Uses

Isopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired. Isopropyl myristate is being studied as a skin enhancer. It is also used as a pesticide against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration.[2]

It is used as a solvent in perfume materials.

It is the non-aqueous component of the two-phase mouthwash, Dentyl pH, where it removes bacteria from the oral cavity.

It is also used in the removal process of prosthetic make-up.

It is also used in flea and tick products for pets.

The hydrolysis of the ester from isopropyl myristate can liberate the acid and the alcohol. The acid could be responsible for decreasing of the pH value of formulations.[3] [4]

References

  1. ↑ MSDS for isopropyl myristate
  2. ↑ Anti-Lice Treatments
  3. ↑ Wen, Z.; Fang, L. and He, Z. (2009). Effect of chemical enhancers on percutaneous absorption of daphnetin in isopropyl myristate vehicle across rat skin in vitro. Drug Deliv, 16: 214-223
  4. ↑ Engelbrecht, T.; Demé, B.; Dobner, B. and Neubert, R. (2012). Study of the influence of the penetration enhancer isopropyl myristate on the nanostructure of stratum corneum lipid model membranes using neutron diffraction and deuterium labelling. Skin Pharmacol Physiol, 25:200-7
  • Record in the Household Products Database of NLM
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