Inositol-hexakisphosphate kinase

Inositol-hexakisphosphate kinase
Identifiers
EC number 2.7.4.21
CAS number 176898-37-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Inositol-hexakisphosphate kinase (EC 2.7.4.21, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase) is an enzyme with systematic name ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase.[1][2][3] This enzyme catalyses the following chemical reaction

(1) ATP + 1D-myo-inositol hexakisphosphate ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
(2) ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown)

Three mammalian isoforms are known to exist.

See also

References

  1. ↑ Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH (November 1999). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Current Biology. 9 (22): 1323–6. doi:10.1016/S0960-9822(00)80055-X. PMID 10574768.
  2. ↑ Schell MJ, Letcher AJ, Brearley CA, Biber J, Murer H, Irvine RF (November 1999). "PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase". FEBS Letters. 461 (3): 169–72. doi:10.1016/S0014-5793(99)01462-3. PMID 10567691.
  3. ↑ Albert C, Safrany ST, Bembenek ME, Reddy KM, Reddy K, Falck J, Bröcker M, Shears SB, Mayr GW (October 1997). "Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells". The Biochemical Journal. 327 ( Pt 2): 553–60. PMC 1218829. PMID 9359429.
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